Methyl 4-bromo-2-((2-chlorobenzyl)amino)thiazole-5-carboxylate CAS 1000577-22-9
| CAS No. | 1000577-22-9 |
| Molecular Formula | C12H10BrClN2O2S |
| Molecular Weight | 361.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Methyl 4-bromo-2-((2-chlorobenzyl)amino)thiazole-5-carboxylate (CAS 1000577-22-9), molecular formula C12H10BrClN2O2S and molecular weight 361.64 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 4-bromo-2-((2-chlorobenzyl)amino)thiazole-5-carboxylate (C12H10BrClN2O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10BrClN2O2S |
| Molecular Weight | 361.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 3-(4-Bromophenyl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-49-0)
- 4-(benzyloxy)-3-bromobenzene-1-sulfonyl chloride (CAS 1097095-65-2)
- 3-(4-Bromophenyl)-1-(3-chlorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-65-0)
- 5-Amino-N-(4-bromo-phenyl)-2-chloro-benzenesulfonamide (CAS 380431-07-2)
- 5-Cyclopropoxy-2-ethylnicotinonitrile (CAS 1243475-33-3)
- tert-Butyl 2-(chloromethyl)piperidine-1-carboxylate (CAS 1289387-67-2)
- 3-Bromo-2-chlorobenzoyl chloride (CAS 21900-59-4)
- (6-(methoxycarbonyl)-1H-indol-2-yl)boronic acid (CAS 1150114-47-8)
- Dalbavancin Impurity 60 (CAS CATO-C4X-160260)
- 3,6-Dimethyl-2-thioxohexahydropyrimidine-4-carboxylic acid (CAS 1103826-96-5)
- 5-Chloro-2,4-difluorobenzenesulfonamide (CAS 13656-56-9)
- (R)-3-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 81306-93-6)
- N-[(Piperidin-4-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 57415-51-7)
- TRAF6 Peptide trifluoroacetate salt (CAS 852805-92-6)
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