(3S,4R)-1-(tert-butyl)-4-(p-tolyl)pyrrolidine-3-carboxylic acid CAS 1002732-08-2
| CAS No. | 1002732-08-2 |
| Molecular Formula | C16H23NO2 |
| Molecular Weight | 261.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(3S,4R)-1-(tert-butyl)-4-(p-tolyl)pyrrolidine-3-carboxylic acid (CAS 1002732-08-2), molecular formula C16H23NO2 and molecular weight 261.36 g/mol, is a CATO reference standard with documented purity and traceability.
(3S,4R)-1-(tert-butyl)-4-(p-tolyl)pyrrolidine-3-carboxylic acid (C16H23NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H23NO2 |
| Molecular Weight | 261.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 1 |
Recommended Standards
- N-Isopropyl-2-(phthalazin-1-yl)hydrazinecarbothioamide (CAS 61051-51-2)
- 1-[4-(2-Piperidin-1-ylethoxy)phenyl]propan-1-one (CAS 101255-84-9)
- 5,5-Dimethyl-5,6,8,9,10,11-hexahydrobenzo[4,5]thieno[3,2-e]tetrazolo[1,5-c]pyrimidine (CAS 890093-71-7)
- 2-(4-Isopropylphenyl)-2-(piperidin-1-yl)acetic acid (CAS 1017206-19-7)
- 5-((4-Methoxyphenyl)sulfonamido)nicotinic acid (CAS 627489-32-1)
- 5-(4-Isopropylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride (CAS 865412-32-4)
- 8-Ethyl-2-azaspiro[4.5]decane-4-carboxylic acid (CAS 1340244-46-3)
- 3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-thiol (CAS 1443306-40-8)
- 3-(2-Chloro-5-methylphenyl)benzonitrile (CAS 1365272-10-1)
- 2-(TERT-BUTOXYCARBONYL(2-HYDROXYETHYL)AMINO)ACETIC ACID (CAS 189160-67-6)
- Vildagliptin Impurity 2 (CAS 1036959-23-5)
- Piperazin-1-yl(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone (CAS 1246549-47-2)
- (2S)-N-[(2R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide (CAS 40600-90-6)
- Peptide 441 (CAS CATO-CPTD788441)
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