3-(4-Methoxy-3-(trifluoromethyl)phenyl)propanoic acid CAS 1005205-20-8
| CAS No. | 1005205-20-8 |
| Molecular Formula | C11H11F3O3 |
| Molecular Weight | 248.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-Methoxy-3-(trifluoromethyl)phenyl)propanoic acid.
3-(4-Methoxy-3-(trifluoromethyl)phenyl)propanoic acid (CAS 1005205-20-8), molecular formula C11H11F3O3 and molecular weight 248.20 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(4-Methoxy-3-(trifluoromethyl)phenyl)propanoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 248.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11F3O3 |
| Molecular Weight | 248.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related Methoxy Standards
- 3-(2-Methoxy-5-(trifluoromethyl)phenyl)propanoic acid (CAS 1017779-11-1)
- 3-(2-Methoxy-3-(trifluoromethyl)phenyl)propanoic acid (CAS 1092460-73-5)
- Ethyl 2-(3-methoxy-5-(trifluoromethyl)phenyl)acetate (CAS 1182351-36-5)
- Ethyl 3-methoxy-5-(trifluoromethyl)benzoate (CAS 1214329-30-2)
- Ethyl 3-methoxy-2-(trifluoromethyl)benzoate (CAS 1214329-33-5)
- Ethyl 2-methoxy-6-(trifluoromethyl)benzoate (CAS 1214335-20-2)
- Ethyl 2-methoxy-4-(trifluoromethyl)benzoate (CAS 1214367-10-8)
- 2-(4-Methoxy-3-methyl-5-(trifluoromethyl)phenyl)acetic acid (CAS 1706446-17-4)
Recommended Standards
- D-α-Aspartyl-L-aspartic acid (CAS CATO-CPTD788802)
- 1-(1-Ethyl-5-methyl-1h-pyrazol-4-yl)-4,4,4-trifluorobutane-1,3-dione (CAS 1005678-84-1)
- Phloroglucinol Related Compound 8 (CAS 121449-71-6)
- 1-(1-Ethyl-3-methyl-1h-pyrazol-4-yl)-4,4,4-trifluorobutane-1,3-dione (CAS 1006322-30-0)
- (S,E)-METHYL 2-AMINO-4-PHENYLBUT-3-ENOATE HCL (CAS 1308311-57-0)
- 3-(Chlorosulfonyl)-2,6-difluorobenzoic Acid (CAS 142576-91-8)
- N-(5-Cyclopropoxy-2-(trifluoromethyl)pyridin-4-yl)methanesulfonamide (CAS 1243375-63-4)
- 3-(Pyrrolidin-1-yl)picolinic acid (CAS 1414866-60-6)
- 3-(Benzoyloxy)-2-hydroxybenzoic acid (CAS 107189-08-2)
- 25947-18-6 3,4-dihydroxy-2-(2-methylbutanoyl)-5-(3-methylbut-2-en-1-yl)-4-(4-methylpent-3-enoyl)cyclopent-2-en-1-one AR-1E9195 (CAS 25947-18-6)
- 6-Methyl-2-(4-nitrophenyl)benzothiazole (CAS 488722-57-2)
- 3-(Methylthio)-1,2,4-triazine (CAS 28735-21-9)
- 4-(Pyridin-3-ylsulfonyl)-7-(thiophen-2-yl)-1,4-thiazepane (CAS 1706292-82-1)
- Palmitoyl Tripeptide-5 TFA (CAS 623172-55-4（free base）)
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