8-(trifluoromethyl)-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoxalin-4(5H)-one CAS 1008022-69-2
| CAS No. | 1008022-69-2 |
| Molecular Formula | C12H11F3N2O |
| Molecular Weight | 256.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 8-(trifluoromethyl)-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoxalin-4(5H)-one (C12H11F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 8-(trifluoromethyl)-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoxalin-4(5H)-one (CAS 1008022-69-2), a certified reference material (molecular formula C12H11F3N2O, MW 256.22 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11F3N2O |
| Molecular Weight | 256.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related trifluoromethyl Standards
- 7-(trifluoromethyl)-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoxalin-4(5H)-one (CAS 1009166-71-5)
- 2-((6-(Trifluoromethyl)quinolin-4-yl)amino)ethan-1-ol (CAS 1065076-16-5)
- 1-(1-Ethyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)ethan-1-one (CAS 1312137-42-0)
- 5-(3-(Trifluoromethyl)phenyl)cyclohexane-1,3-dione (CAS 144128-67-6)
- (2-(1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)methanol (CAS 892502-29-3)
- (4-(1-Methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)methanol (CAS 2446481-80-5)
- [1-Methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]methanol (CAS 639784-65-9)
- [2-Methyl-5-(4-trifluoromethyl-phenyl)-furan-3-yl]-methanol (CAS 476155-27-8)
Recommended Standards
- Purpurin (CAS 81-54-9)
- 2,7-Dinitrofluorene (CAS 5405-53-8)
- 2-(1H-pyrazol-1-yl)-4-(1H-tetrazol-1-yl)benzoic acid (CAS 1011404-54-8)
- Dopamine Impurity 73 (CAS CATO-C4X-190873)
- 1-(2-Methyl-1H-imidazol-1-yl)propan-2-one (CAS 31964-03-1)
- 5-Chloromethyl-1H-indazole (CAS 944904-22-7)
- 2-Bromo-3-(dimethylamino)-1-(4-methylphenyl)-propan-1-one hydrochloride (CAS 1965305-18-3)
- 1-[(4-tert-Butylphenyl)methyl]-4-nitro-1h-pyrazole (CAS 1240570-45-9)
- 4-(2,3-Dichloro-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid (CAS 379728-20-8)
- 6-Amino-8-fluoro-3,4-dihydroquinolin-2(1H)-one (CAS 113225-70-0)
- (E)-1,2-Diphenyldiazene (CAS 17082-12-1)
- 3-(1-Methyl-1H-pyrazol-4-yl)aniline (CAS 1089278-81-8)
- Diisotridecyl phthalate (CAS 75359-31-8)
- a-Bag Cell Peptide (1-8) (CAS 87549-53-9)
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