2-Chloro-4-methoxybenzyl chloride CAS 101080-63-1
| CAS No. | 101080-63-1 |
| Molecular Formula | C8H8Cl2O |
| Molecular Weight | 191.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4-methoxybenzyl chloride.
CATO supplies 2-Chloro-4-methoxybenzyl chloride (CAS 101080-63-1), a certified reference material (molecular formula C8H8Cl2O, MW 191.05 g/mol) for analytical method development and quality control.
2-Chloro-4-methoxybenzyl chloride (C8H8Cl2O) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8Cl2O |
| Molecular Weight | 191.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 1-chloro-2-(chloromethyl)-4-methoxybenzene (CAS 101079-83-8)
- 2-Chloro-1-(3-chloro-phenyl)-ethanol (CAS 106262-93-5)
- 1-Chloro-4-(2-chloroethoxy)benzene (CAS 13001-28-0)
- 2-Chloro-4-(chloromethyl)-1-methoxybenzene (CAS 13719-57-8)
- 1-Chloro-4-(chloromethyl)-2-methoxybenzene (CAS 13726-18-6)
- (R)-2-chloro-1-(3-chlorophenyl)ethanol (CAS 142763-10-8)
- (S)-2-Chloro-1-(3-chlorophenyl)ethanol (CAS 174699-78-6)
- (S)-2-Chloro-1-(4-chlorophenyl)ethanol (CAS 178460-78-1)
Recommended Standards
- 5-Bromo-2-methoxypyridine-d3 (CAS 1185319-63-4)
- 1,2-Dichloro-5-methoxy-3-methylbenzene (CAS 112369-07-0)
- 2-Bromo-5-methoxypyridine-d (CAS 1185315-90-5)
- 2-(2,3-Dichlorophenyl)ethanol (CAS 114686-85-0)
- 4-(3-Amino-4-methylphenyl)phthalazin-1-ol (CAS 843638-25-5)
- (1R,3S)-3-(methylamino)cyclohexan-1-ol (CAS 1932174-47-4)
- 2-Methoxyquinoline-6-boronic acid pinacol ester, >97% (CAS 1201644-36-1)
- Bis(phenylsulfonyl)sulfide (CAS 4388-22-1)
- Naphthalen-1-ylhydrazine Hydrochloride (CAS 2243-56-3)
- 3-Acetyl-7-hydroxy-2H-chromen-2-one (CAS 10441-27-7)
- 2-Methoxyethyl (5-(chlorosulfonyl)naphthalen-1-yl)carbamate (CAS 728864-82-2)
- 2-(3-Chlorophenyl)-5-((2-methylpiperidin-1-yl)methyl)benzo[d]oxazole (CAS 1706449-59-3)
- (1S,2R,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol (CAS 470-08-6)
- a-Bag Cell Peptide (1-8) (CAS 87549-53-9)
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