Cefixime Impurity 104 CAS 101156-41-6
| CAS No. | 101156-41-6 |
| Molecular Formula | C24H23BrN2O5S |
| Molecular Weight | 531.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cefixime Impurity 104 (CAS 101156-41-6, C24H23BrN2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cefixime Impurity 104 (C24H23BrN2O5S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H23BrN2O5S |
| Molecular Weight | 531.42 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Cefixime Standards
- Cefixime Impurity 97 (CAS CATO-C4X-113997)
- Cefixime Impurity 98 (CAS CATO-C4X-113998)
- Cefixime Impurity 24 (CAS 79368-92-6)
- Cefixime Impurity 31 (CAS CATO-C4X-113931)
- Cefixime Impurity 68 (CAS CATO-C4X-113968)
- Cefixime Impurity 71 (CAS CATO-C4X-113971)
- Cefixime Impurity 112 (CAS CATO-C4X-1139112)
- Cefixime Impurity 75 (CAS CATO-C4X-113975)
Recommended Standards
- Bortezomib Impurity 18 (CAS CATO-C4X-107218)
- Levoketoconazole (CAS 142128-57-2)
- 4-(Ethoxycarbonyl)-3-methoxybenzoic acid (CAS 5462-88-4)
- 1-(4-(4-((2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethan-1-one (CAS 79156-75-5)
- Etrasimod Impurity 69 (CAS CATO-C4X-321469)
- Duloxetine Impurity 47 (CAS 22176-00-7)
- Dotinurad Impurity 174 (CAS CATO-C4X-2494174)
- 6-Chloro-3-ethoxy-2-fluorobenzoic acid (CAS 2385350-59-2)
- Dimetindene EP Impurity C (CAS 92726-29-9)
- 2-(Trifluoromethoxy)pyridin-3-amine (CAS 1221171-94-3)
- 4-(2-(Oxiran-2-yl)ethyl)morpholine (CAS 1644306-94-4)
- 1-(3,5-Dichlorophenyl)-3-(4-methoxyphenyl)propan-1-one (CAS 898776-34-6)
- Entrectinib (CAS 1108743-60-7)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
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