2-Hydroxy-4-methyl-5-nitrobenzaldehyde CAS 101421-77-6
| CAS No. | 101421-77-6 |
| Molecular Formula | C8H7NO4 |
| Molecular Weight | 181.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Hydroxy-4-methyl-5-nitrobenzaldehyde (CAS 101421-77-6), molecular formula C8H7NO4 and molecular weight 181.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Hydroxy-4-methyl-5-nitrobenzaldehyde (C8H7NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Hydroxy-4-methyl-5-nitrobenzaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7NO4 |
| Molecular Weight | 181.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 1-(2-Hydroxy-4-nitrophenyl)ethanone (CAS 1834-91-9)
- 1-(2-Hydroxy-6-nitrophenyl)ethan-1-one (CAS 383124-44-5)
- 1-(3-Hydroxy-2-nitrophenyl)ethanone (CAS 53967-72-9)
- 1-(3-Hydroxy-4-nitrophenyl)ethan-1-one (CAS 89942-63-2)
- 1-(4-Hydroxy-2-nitrophenyl)ethanone (CAS 948550-13-8)
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Recommended Standards
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- N-((8-methyl-8-azabicyclo[3.2.1]Octan-3-yl)methyl)heptan-4-amine (CAS 1178501-62-6)
- 5-Nitro-2-(p-tolylthio)benzonitrile (CAS 849458-07-7)
- Bis(2-methylpropyl)[(oxiran-2-yl)methyl]amine (CAS 51734-85-1)
- Mercury(II) perchlorate hydrate (CAS 304656-34-6)
- 3-(3-Hydroxy-1-oxo-1H-inden-2-yl)-4,6-dioxo-5-(3-(trifluoromethyl)phenyl)-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid (CAS 321521-98-6)
- CIS-TERT-BUTYL 3-(AMINOMETHYL)-2-METHYLPYRROLIDINE-1-CARBOXYLATE (CAS 1931924-31-0)
- 5-(4-Methoxyphenyl)imidazolidine-2,4-dione (CAS 6617-78-3)
- 3-Hydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one (CAS 6068-76-4)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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