N-(5-Carbamoyl-2-(piperidin-1-yl)phenyl)-2-(4-chlorophenyl)thiazole-4-carboxamide CAS 1016434-01-7
| CAS No. | 1016434-01-7 |
| Molecular Formula | C22H21ClN4O2S |
| Molecular Weight | 440.95 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(5-Carbamoyl-2-(piperidin-1-yl)phenyl)-2-(4-chlorophenyl)thiazole-4-carboxamide is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-(5-Carbamoyl-2-(piperidin-1-yl)phenyl)-2-(4-chlorophenyl)thiazole-4-carboxamide (CAS 1016434-01-7) is a high-purity analytical reference standard with the molecular formula C22H21ClN4O2S and a molecular weight of 440.95 g/mol.
Structurally, N-(5-Carbamoyl-2-(piperidin-1-yl)phenyl)-2-(4-chlorophenyl)thiazole-4-carboxamide (C22H21ClN4O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 440.95 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21ClN4O2S |
| Molecular Weight | 440.95 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related N Standards
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Recommended Standards
- Sertindole (CAS 106516-24-9)
- N-(4-Chlorophenyl)-1-ethyl-7-methyl-N-(4-methyl-4,5-dihydrothiazol-2-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide (CAS 870757-00-9)
- Sotagliflozin Impurity 4 (CAS 1018899-73-4)
- (4Z)-N-[(4-Chlorophenyl)methoxy]-1-(4-methylphenyl)-2-phenyl-4,5,6,7-tetrahydro-1H-indol-4-imine (CAS 338757-84-9)
- 2-(Propylsulfanyl)-4-(trifluoromethyl)-5H,6H,7H,8H,9H,10H-cycloocta[b]pyridine-3-carbonitrile (CAS 626228-66-8)
- Heptyl Ether (CAS 629-64-1)
- 2-Mercaptoacetamide (CAS 758-08-7)
- 6-{[(3-chlorophenyl)methyl]sulfanyl}imidazo[2,1-b][1,3]thiazole-5-carbonitrile (CAS 338404-72-1)
- (S)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethan-1-ol (CAS 287394-20-1)
- 3-(Perfluorophenoxy)propan-1-amine hydrochloride (CAS 1051368-92-3)
- 1-(2-Chlorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 400877-15-8)
- (2-Fluoro-3,5-diformylphenyl)boronic acid (CAS 870778-85-1)
- 3-CYANO-4-FLUOROBENZENE-1-SULFONYL CHLORIDE 3-CYANO-4-FLUOROBENZENESULFONYL CHLORIDE 3-CYANO-4-FLUOROBENZENESULPHONYL CHLORIDE 351003-23-1 4-FLUORO-3-CYANOBENZENESULFONYL CHLORIDE 4-FLUORO-3-CYANOBENZENESULPHONYL CHLORIDE 5-(CHLOROSULFONYL)-2-FLUOROBENZENECARBONITRILE BENZENESULFONYL CHLORIDE, 3-CYANO-4-FLUORO- XF10062 (CAS 351003-23-1)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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