N-(3-(Chloromethyl)-5-nitrophenyl)acetamide CAS 1018448-90-2
| CAS No. | 1018448-90-2 |
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(3-(Chloromethyl)-5-nitrophenyl)acetamide.
N-(3-(Chloromethyl)-5-nitrophenyl)acetamide (CAS 1018448-90-2) is a high-purity analytical reference standard with the molecular formula C9H9ClN2O3 and a molecular weight of 228.63 g/mol.
N-(3-(Chloromethyl)-5-nitrophenyl)acetamide (C9H9ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(3-(Chloromethyl)-5-nitrophenyl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-[2-(chloromethyl)-4-nitrophenyl]acetamide (CAS 1171021-29-6)
- 3-(chloromethyl)-1-(2,6-difluorophenyl)-1H-pyrazole (CAS 1423025-88-0)
- 3-(Chloromethyl)-1-(2,4-difluorophenyl)-1h-pyrazole (CAS 1480177-94-3)
- 8-(Chloromethyl)-4H-benzo[d][1,3]dioxine-6-carboxylic acid (CAS 884325-48-8)
- 8-(Chloromethyl)-1,3-dimethyl-2,3,6,9-tetrahydro-1h-purine-2,6-dione (CAS 64398-14-7)
- 8-(Chloromethyl)-3,7-dimethyl-3,7-dihydro-1h-purine-2,6-dione (CAS 4921-56-6)
- 2-(Chloromethyl)-5-fluoro-7-hydroxyquinazolin-4(3H)-one (CAS 2360859-98-7)
- 2-Chloromethyl-6-nitrobenzo[d]thiazole, 97% (CAS 188624-36-4)
Recommended Standards
- 2-(5-Chloro-2-ureidophenyl)acetic Acid (CAS 100666-71-5)
- 4-Chloro-3-(difluoromethyl)-5-phenyl-1H-pyrazole (CAS 1029636-02-9)
- 5-Chloro-3-((trifluoromethyl)thio)pyridin-2-amine (CAS 2384462-96-6)
- 2-(6-Chloro-4h-benzo[d][1,3]dioxin-8-yl)acetic acid (CAS 1050910-10-5)
- 2,4-Dichloro-5-(difluoromethyl)pyridine-3-sulfonamide (CAS 1806804-32-9)
- 4-Amino-1-ethyl-5-methyl-2-phenyl-1H-pyrazol-3(2H)-one (CAS 114682-26-7)
- N-(2,4-difluorophenyl)-3-((3-(trifluoromethyl)benzyl)thio)thiophene-2-carboxamide (CAS 250714-47-7)
- METHYL 4-(3-AMINOPHENOXY)BENZOATE (CAS 192768-38-0)
- 3-Chloro-2-(2-methylpropoxy)pyridin-4-ol (CAS 1881293-61-3)
- 2-(5-Isopropyl-1,3,4-oxadiazol-2-yl)ethan-1-amine (CAS 944907-23-7)
- Pentadec-1-yne (CAS 765-13-9)
- Chlorodimethyl(4-phenylbutyl)silane (CAS 32328-67-9)
- 2-(Aminomethyl)pyrrolidine-1-carboximidamide (CAS 791748-40-8)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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