Raloxifene Impurity 23 CAS 102005-47-0
| CAS No. | 102005-47-0 |
| Molecular Formula | C15H21NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 299.80 g/mol gives Raloxifene Impurity 23 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Raloxifene Impurity 23 (CAS 102005-47-0, C15H21NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Raloxifene Impurity 23 (C15H21NO3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21NO3 HCl |
| Molecular Weight | 299.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Raloxifene Standards
- Raloxifene Impurity 19 (CAS 1100049-65-7)
- Raloxifene Impurity 18 (CAS 1100049-66-8)
- Raloxifene EP Impurity A (CAS 1159977-58-8)
- Raloxifene-d4 Bismethyl Ether (CAS 1185006-58-9)
- Raloxifene D4 (CAS 1185076-44-1)
- Raloxifene-d4 HCl (CAS 1188263-47-9)
- Raloxifene Impurity 4 (CAS 1191901-07-1)
- Raloxifene Impurity 13 (CAS 1196-81-2)
Recommended Standards
- Tiotropium impurity 49 (CAS CATO-C4X-176449)
- Iomeprol Impurity 5 (CAS CATO-C4X-18205)
- Fluchlorfenapyr Impurity 38 (CAS 2129147-03-9)
- 2-(3-Piridyl)thiazolidine-4-carboxylic acid (CAS 59777-95-6)
- N-(2-Methoxybenzyl)pentan-2-amine (CAS 1019594-89-8)
- (S)-3-(2,6-Difluorophenyl)piperazin-2-one (CAS 1240589-21-2)
- (2-(Thiophen-2-yl)pyrimidin-5-yl)methanol (CAS 921939-13-1)
- 2-Amino-7-bromoquinolin-3-ol hydrobromide (CAS 2500655-56-9)
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-sulfonyl chloride (CAS 1443980-37-7)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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