Lamivudine Impurity 28 CAS 1020151-61-4

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.1020151-61-4
Molecular FormulaC14H23ClO3S
Molecular Weight306.85 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Lamivudine Impurity 28 CAS 1020151-61-4 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 306.85 g/mol gives Lamivudine Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Lamivudine Impurity 28 (CAS 1020151-61-4, C14H23ClO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Lamivudine Impurity 28 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 306.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC14H23ClO3S
Molecular Weight306.85 g/mol
Purity>90%
StorageStore in a cool place (≤25°C), keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1988
Halogen ContentCl-containing
Sulfur Atoms1

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