Bupropion Impurity 72 CAS 102141-11-7
| CAS No. | 102141-11-7 |
| Molecular Formula | C13H20ClNO |
| Molecular Weight | 241.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Bupropion Impurity 72 (CAS 102141-11-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H20ClNO and a molecular weight of 241.76 g/mol.
Structurally, Bupropion Impurity 72 (C13H20ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 241.76 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bupropion Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H20ClNO |
| Molecular Weight | 241.76 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bupropion Standards
- Bupropion Impurity 71 (CAS 102141-12-8)
- Bupropion Impurity 73 (CAS 292055-72-2)
- (S)-Bupropion (CAS CATO-C4X-120334)
- (R)-Bupropion (CAS CATO-C4X-120335)
- Bupropion impurity 67 (CAS 1049974-40-4)
- Bupropion Impurity 68 (CAS CATO-C4X-120368)
- Bupropion USP Related Compound G (CAS 34911-51-8)
- Bupropion D9 (CAS 150988-80-0)
Recommended Standards
- (S, R)-Hydrobupropion (CAS CATO-C4X-120339)
- Tulobuterol Impurity 18 (CAS CATO-C4X-213418)
- (R, S)-Hydrobupropion (CAS CATO-C4X-120338)
- 2-(((4-Chlorophenyl)thio)methyl)piperidine (CAS 101798-77-0)
- Latamoxef Impurity 4 (CAS 76945-69-2)
- Benzylpenicillin (Benzathine) Tetrahydrate EP Impurity C (CAS CATO-C4X-189943)
- Tofacitinib Impurity 139 (CAS CATO-C4X-1079139)
- (1-Benzyl-3,5-dimethyl-1h-pyrazol-4-yl)methanamine (CAS 956567-89-8)
- 5-Bromo-4-methyl-1,3-thiazole-2-carbonitrile (CAS 859481-85-9)
- 2-(tert-Butylamino)-2-oxoethyl methylcarbamimidothioate hydrochloride (CAS 447412-45-5)
- 8-Benzyl-7-isopropyl-2,5-dioxa-8-azaspiro[3.4]Octane (CAS 1556097-40-5)
- 9-Hydrazinoacridine (CAS 3407-93-0)
- 4-Amino-3-bromo-6-fluoroindazole (CAS 885522-95-2)
- FMRF Amide Related Peptide. (CAS 149471-12-5)
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