2,2-Bis(4-isocyanatophenyl)hexafluoropropane CAS 10224-18-7
| CAS No. | 10224-18-7 |
| Molecular Formula | C17H8F6N2O2 |
| Molecular Weight | 386.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 386.25 g/mol gives 2,2-Bis(4-isocyanatophenyl)hexafluoropropane distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2,2-Bis(4-isocyanatophenyl)hexafluoropropane (CAS 10224-18-7) is a high-purity analytical reference standard with the molecular formula C17H8F6N2O2 and a molecular weight of 386.25 g/mol.
The molecular framework of 2,2-Bis(4-isocyanatophenyl)hexafluoropropane (C17H8F6N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H8F6N2O2 |
| Molecular Weight | 386.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
- 2-(4-Isocyanatophenyl)-5-(trifluoromethyl)pyridine (CAS 906352-73-6)
- 4,4＇-Bis(isocyanatophenyl)oxide (CAS 4128-73-8)
- 2-(3-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 787591-43-9)
- 2-(4-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 380430-64-8)
- (E)-1-(4-Isocyanatophenyl)-2-phenyldiazene (CAS 321951-62-6)
- 1-(4-Isocyanatophenyl)-4-methylpiperazine (CAS 879896-39-6)
- 4-(3-Isocyanatophenyl)-2-methyl-1,3-thiazole (CAS 852180-41-7)
- 4-(4-Isocyanatophenyl)-2-methyl-1,3-thiazole (CAS 857283-94-4)
Recommended Standards
- 2-(2,6-Dichlorobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 1009520-26-6)
- Dimethyl 5-(3,4-dichlorophenyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (CAS 110271-25-5)
- Pazopanib Impurity 61 (CAS CATO-C4X-172561)
- 5-(2,4-Bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl)-4-methyloxazole (CAS 1431425-91-0)
- 1,1'-[2-[[3-[[(9Z)-1-OXo-9-octadecen-1-yl]oxy]-2,2-bis[[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]methyl]propoxy]methyl]-2-[[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]methyl]-1,3-propanediyl] di-(9Z)-9-octadecenoate (CAS 70984-13-3)
- 4-Amino-2-methylnicotinaldehyde (CAS 1060809-70-2)
- 4-Chloro-1-(4-methoxy-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1416346-15-0)
- 13-(4-Nitrophenyl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione (CAS 57663-56-6)
- 4-Aminoisoquinolin-1(2H)-one hydrochloride (CAS 108127-91-9)
- 5-Isopropylisoxazol-3(2H)-one (CAS 10004-47-4)
- [3-(2-fluorophenoxy)phenyl]methanamine (CAS 1061651-05-5)
- (S)-1-(1H-Benzimidazol-2-yl)-2-methylpropylamine Hydrochloride (CAS 184685-11-8)
- 4-((1H-1,2,4-Triazol-1-yl)methyl)aniline hydrochloride (CAS 144235-64-3)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com