5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-8,9-dimethoxy-3-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-2-one CAS 1024594-03-3
| CAS No. | 1024594-03-3 |
| Molecular Formula | C22H21ClFN3O3S |
| Molecular Weight | 461.94 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-8,9-dimethoxy-3-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-2-one.
CATO supplies 5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-8,9-dimethoxy-3-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-2-one (CAS 1024594-03-3), a certified reference material (molecular formula C22H21ClFN3O3S, MW 461.94 g/mol) for analytical method development and quality control.
Structurally, 5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-8,9-dimethoxy-3-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-2-one (C22H21ClFN3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 461.94 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21ClFN3O3S |
| Molecular Weight | 461.94 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related chloro Standards
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Recommended Standards
- MK-5108 (CAS 1010085-13-8)
- 2-((4-(4-Chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(1H-indazol-6-yl)acetamide (CAS 476483-73-5)
- 4-(3-(2-(2-Chlorophenyl)-2-oxoethyl)-2-hydroxy-4,6-dimethoxyphenyl)-1-methylpiperidin-3-yl acetate (CAS 1415560-71-2)
- 1-((4-(Tert-butyl)phenyl)sulfonyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 260368-22-7)
- Otamixaban (CAS 193153-04-7)
- (1s)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)ethan-1-ol (CAS 1372912-64-5)
- 5-Bromo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine (CAS 1260671-35-9)
- tert-Butyl 4-(2-chlorophenyl)-2,6-dioxo-1,3-oxazinane-3-carboxylate (CAS 886362-57-8)
- Brimonidine EP Impurity G HCl (CAS CATO-C4X-156637)
- (R)-7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-1(2H)-one (CAS 2165628-91-9)
- 1-(3,4-Dihydroquinolin-1(2H)-yl)-2-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one (CAS 483284-59-9)
- 2-(2-methylpropyl)-2,3-dihydro-1H-isoindol-4-amine (CAS 1017462-39-3)
- Methyl 4-(difluoromethoxy)-3-nitrobenzoate (CAS 1154278-25-7)
- Semaglutide impurity 29 (CAS 110990-08-4)
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