Pimecrolimus Impurity 1 CAS 1025113-89-6
| CAS No. | 1025113-89-6 |
| Molecular Formula | C42H66ClNO11 |
| Molecular Weight | 796.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Pimecrolimus Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Pimecrolimus Impurity 1 (CAS 1025113-89-6) is a certified pharmaceutical impurity reference standard with the molecular formula C42H66ClNO11 and a molecular weight of 796.43 g/mol.
Pimecrolimus Impurity 1 (C42H66ClNO11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C42H66ClNO11 |
| Molecular Weight | 796.43 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pimecrolimus Standards
- Pimecrolimus Impurity 11 (CAS CATO-C4X-173111)
- Pimecrolimus Impurity 7 (CAS CATO-C4X-17317)
- Pimecrolimus Impurity 8 (CAS CATO-C4X-17318)
- Pimecrolimus (CAS 137071-32-0)
- Pimecrolimus Impurity 12 (CAS CATO-C4X-173112)
- Pimecrolimus Impurity 13 (CAS CATO-C4X-173113)
- Pimecrolimus Impurity 14 (CAS CATO-C4X-173114)
- Pimecrolimus Impurity 16 (CAS CATO-C4X-173116)
Recommended Standards
- 5,10,15,20-Tetrakis(3-methoxyphenyl)porphyrinatonickel (CAS 24249-30-7)
- 2-[[(1S)-1-[(2S,4R)-2-[[(1R)-2-[[2-[[(1R)-1-(aminomethyl)-2-[[(1S)-2-amino-2-oxo-1-(sulfanylmethyl)ethyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-[4-(4-methylthiazol-5-yl)phenyl]-2-oxo-ethyl]carbamoyl]-4-hydroxy-pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]amino]acetyl chloride (CAS 2756688-02-3)
- 5,10,15-Tri(pentafluorophenyl)corrole (CAS 262280-80-8)
- (SP-4-2)-Bromo[1,1'-[(oxydi-2,1-phenylene)]bis[1,1-diphenylphosphine-κP]](2,4,6-trimethylphenyl)nickel (CAS 2097609-32-8)
- Dopamine Impurity 4 (CAS 61404-93-1)
- Pramipexole Impurity 83 DiHCl (CAS 104632-25-9)
- Apalutamide Impurity 7 (CAS CATO-C4X-27497)
- 2-(3-Oxodecahydroquinoxalin-2-yl)-N-propylacetamide (CAS 1428138-99-1)
- 1-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrol-2-yl)ethan-1-ol (CAS 338397-81-2)
- Methyl 1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridine-2-carboxylate (CAS 1196046-85-1)
- Valsartan Impurity 141 (CAS CATO-C4X-1057141)
- Methyl N-((tert-butoxycarbonyl)glycyl)-N-methylglycinate (CAS 174311-10-5)
- Tert-butyl (2S,3S)-3-(4-(trifluoromethyl)phenyl)aziridine-2-carboxylate (CAS 1980007-28-0)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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