(2E)-3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one CAS 1025643-55-3
| CAS No. | 1025643-55-3 |
| Molecular Formula | C21H13ClF3NO2 |
| Molecular Weight | 403.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2E)-3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one.
(2E)-3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one (CAS 1025643-55-3) is a high-purity analytical reference standard with the molecular formula C21H13ClF3NO2 and a molecular weight of 403.78 g/mol.
(2E)-3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one (C21H13ClF3NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H13ClF3NO2 |
| Molecular Weight | 403.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- (2E)-3-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-phenylprop-2-en-1-one (CAS 1025208-97-2)
- 2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-N'-(2-cyanoethanimidoyl)acetohydrazide (CAS 338979-35-4)
- 3-Chloro-2-({4-methyl-5-[2-(1H-1,2,4-triazol-1-yl)propan-2-yl]-4H-1,2,4-triazol-3-yl}sulfanyl)-5-(trifluoromethyl)pyridine (CAS 339026-48-1)
- 4-(4-(2-Chloro-5-nitrophenoxy)butoxy)benzene-1-sulfonyl fluoride (CAS 31185-45-2)
- N-(9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide (CAS 183721-15-5)
- 2-(2-(4-((3-Chloro-2-methylphenyl)amino)-4-oxobutanoyl)hydrazine-1-carbonyl)benzoic acid (CAS 315675-95-7)
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- 2-Chloro-4-nitrophenyl 5-(1,2,3-thiadiazol-4-yl)thiophene-2-sulfonate (CAS 338400-22-9)
Recommended Standards
- 1-((2-Chlorobenzyl)oxy)-2-(3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-b]pyridine (CAS 400087-59-4)
- 3958-03-0 Tetrabromothiophene Thiophene, tetrabromo- (8CI)(9CI) EINECS 223-554-7 NSC 65427 2,3,4,5-Tetrabromothiophene (CAS 3958-03-0)
- 2-(4-Chlorophenyl)-1-((3-(trifluoromethyl)benzyl)oxy)-1H-imidazo[4,5-b]pyridine (CAS 339009-91-5)
- Pyridin-3-yl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrole-2-sulfonate (CAS 338407-25-3)
- 2-(4,4-Diethyl-2,5-dioxoimidazolidin-1-yl)acetic acid (CAS 714-71-6)
- (1-(2-Methoxybenzyl)piperidin-3-yl)methanol (CAS 415714-41-9)
- N-(1-ethoxypropan-2-yl)thieno[3,2-d]pyrimidin-4-amine (CAS 1249387-10-7)
- Ursodeoxycholic Acid Impurity 123 (CAS 10601-78-2)
- 6-Iodo-4-methylpyridine-2-sulfonyl chloride (CAS 1393558-46-7)
- tert-Butyl 4-formyl-4-(4-(methylthio)-phenyl)piperidine-1-carboxylate (CAS 1673527-15-5)
- 1-(Cyclopropylmethyl)-4-((cyclopropylmethyl)thio)cyclohexanecarbonitrile (CAS 916160-36-6)
- 1-(3-Butoxyphenyl)-2,2,2-trifluoroethan-1-one (CAS 1443343-46-1)
- Ethyl 5-chloro-3-phenyl-1H-indole-2-carboxylate (CAS 21139-32-2)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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