1-(4-Fluorophenyl)-5-iodo-1H-indazole CAS 1025762-98-4
| CAS No. | 1025762-98-4 |
| Molecular Formula | C13H8FIN2 |
| Molecular Weight | 338.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(4-Fluorophenyl)-5-iodo-1H-indazole (C13H8FIN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-(4-Fluorophenyl)-5-iodo-1H-indazole (CAS 1025762-98-4) is a high-purity analytical reference standard with the molecular formula C13H8FIN2 and a molecular weight of 338.12 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8FIN2 |
| Molecular Weight | 338.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Fluorophenyl Standards
- 2-(4-Fluorophenyl)-6-iodoimidazo[1,2-a]pyridine (CAS 478040-44-7)
- 4-(4-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-3-yl)benzene-1,3-diol (CAS 385401-09-2)
- (5-((4-Fluorophenyl)sulfonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol (CAS 318469-24-8)
- 1-(4-Fluorophenyl)-3-[3-(trifluoromethyl)benzyl]tetrahydro-2H-imidazol-2-one (CAS 866149-50-0)
- 2-(2-Fluorophenyl)-5-phenyl-6,6,6-trifluorohex-3-yne-2,5-diol (CAS 240131-31-1)
- 2-(3-Fluorophenyl)-5-phenyl-6,6,6-trifluorohex-3-yne-2,5-diol (CAS 243139-66-4)
- 2-(4-Fluorophenyl)-5-phenyl-6,6,6-trifluorohex-3-yne-2,5-diol (CAS 247220-83-3)
- Ethyl 4-(((3-(4-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)amino)-4-oxobutanoate (CAS 954616-56-9)
Recommended Standards
- Eltrombopag Impurity 88 (CAS CATO-C4X-119888)
- tert-Butyl (6-fluoro-4-iodopyridin-3-yl)carbamate (CAS 1034658-67-7)
- 4-(2-(Trichlorosilyl)ethyl)benzenesulfonyl chloride (CAS 79793-00-3)
- tert-Butyl (2-fluoro-4-iodopyridin-3-yl)carbamate (CAS 1034658-69-9)
- 3-Fluoro-2-(pyrimidin-2-yl)benzoic acid (CAS 1293285-04-7)
- (2-Amino-5-cyclopropylphenyl)dimethylphosphine oxide (CAS 2222954-35-8)
- Nickel, [N,N'-(1,2-dimethyl-1,2-ethanediylidene)bis[3-(diphenylphosphino-κP)-1-propanamine-κN]]- (CAS 1469910-16-4)
- (S)-2-Amino-N-(4-(3,5-dimethylphenoxy)-3-methylbenzyl)propanamide hydrochloride (CAS 1821908-49-9)
- 1-(3,4-dichloro-2-hydroxyphenyl)propan-1-one (CAS 777067-72-8)
- Upadacitinib Impurity 174 (CAS CATO-C4X-2405174)
- (1-(6-Chloropyrimidin-4-yl)azetidin-3-yl)methanol (CAS 1420871-29-9)
- 3,3-Diethyl-2,2-oxathiacarBocyanineiodide (CAS 15185-43-0)
- (2E)-N-(2,4-Difluorophenyl)-3-(4-ethoxyphenyl)prop-2-enamide (CAS 329777-48-2)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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