Milbemycin Oxime EP Impurity H CAS 1025877-03-5
| CAS No. | 1025877-03-5 |
| Molecular Formula | C31H43NO7 |
| Molecular Weight | 541.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Milbemycin Oxime EP Impurity H (CAS 1025877-03-5, C31H43NO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Milbemycin Oxime EP Impurity H (C31H43NO7) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Milbemycin Oxime EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C31H43NO7 |
| Molecular Weight | 541.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 1 |
Related Milbemycin Standards
- Milbemycin A3 Oxime (CAS 114177-14-9)
- Milbemycin Oxime EP Impurity E (CAS 86691-97-6)
- Milbemycin Impurity 5 (CAS 51596-12-4)
- Milbemycin Oxime EP Impurity A (CAS 51596-11-3)
- Milbemycin (CAS 51570-36-6)
- Milbemycin A4 Oxime (CAS 93074-04-5)
- Milbemycin Oxime EP Impurity I (CAS CATO-C4X-169811)
- Milbemycin Oxime EP Impurity F (CAS 86691-98-7)
Recommended Standards
- Ethyl 2-(2-((3-cyano-6-phenyl-4-(p-tolyl)pyridin-2-yl)thio)acetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 332161-68-9)
- Ethyl 2-(2-((3-cyano-4-phenyl-6-(p-tolyl)pyridin-2-yl)thio)acetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 332053-33-5)
- GSK343 (CAS 1346704-33-3)
- 5-((3-(4-Ethoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(4-methoxybenzyl)-2-thioxothiazolidin-4-one (CAS 623934-73-6)
- Tolvaptan Impurity 57 (CAS CATO-C4X-195557)
- Etoricoxib Impurity 73 (CAS 1937252-96-4)
- Tioconazole EP Impurity C (CAS 119386-76-4)
- N-(4-Hydroxyphenyl)-N-methanesulfonylmethanesulfonamide (CAS 1323367-45-8)
- 1-Acetyl-2-methyl-1,2,4-triazinane-3,5-dione (CAS 89598-69-6)
- 2-(4-(Aminomethyl)pyridin-2-yl)isothiazolidine 1,1-dioxide dihydrochloride (CAS 2251054-25-6)
- N-Benzyl-2-[(2-bromoacetyl)amino]-N-methylbenzamide (CAS 1138445-82-5)
- (2-Amino-6-chloro-3-methylphenyl)methanol (CAS 1603354-77-3)
- Methyl 2-aminopropanoate (CAS 7625-53-8)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
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