Sulfadiazine impurity 4 CAS 1027941-35-0
| CAS No. | 1027941-35-0 |
| Molecular Formula | C12H12N4O3S |
| Molecular Weight | 292.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sulfadiazine impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sulfadiazine impurity 4 (CAS 1027941-35-0, C12H12N4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sulfadiazine impurity 4 (C12H12N4O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 292.31 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H12N4O3S |
| Molecular Weight | 292.31 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Sulfadiazine Standards
- Sulfadiazine EP Impurity E (CAS 127-74-2)
- Sulfadiazine lmpurity 6 (CAS CATO-C4X-150416)
- Sodium Sulfadiazine (CAS 547-32-0)
- Sulfadiazine Impurity 1 (4-Hydroxy Sulfadiazine) (CAS 56305-66-9)
- Sulfadiazine lmpurity 4 (CAS CATO-C4X-150414)
- Sulfadiazine-13C6 (CAS 1189426-16-1)
- Sulfadiazine-D4 (CAS 1020719-78-1)
- Sulfadiazine (CAS 68-35-9)
Recommended Standards
- Tert-butyl2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (CAS 1179337-15-5)
- Torasemide Impurity 20 (CAS CATO-C4X-183620)
- (((2,2-Difluoropropane-1,3-diyl)bis(oxy))bis(methylene))dibenzene (CAS 1339869-86-1)
- Acetylcysteine Impurity 8 (CAS CATO-C4X-15328)
- Esomeprazol Impurity H431 (CAS 1227380-90-6)
- Buspirone EP Impurity H (CAS 2708578-34-9)
- Flurbiprofen Impurity 41 (CAS 535-11-5)
- 6-(2-Chlorobenzyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 1119452-25-3)
- 3-(4-(Pyridin-2-yl)thiazol-2-yl)aniline (CAS 886507-85-3)
- (1-Methyl-5-phenyl-1H-pyrazol-4-yl)boronic acid (CAS 1858252-28-4)
- 1,9-Dioxa-4-azaspiro[5.5]undecane (CAS 402938-74-3)
- 6-Bromo-3-cyclopropoxy-2-fluoropyridine (CAS 1243387-03-2)
- (4-Methyl-4-(pyridin-3-yl)pyrrolidin-3-yl)methanol (CAS 1823671-99-3)
- Cholecystokinin Octapeptide (1-4) (desulfated) (CAS 80790-40-5)
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