4-(Trifluoromethyl)furan-2(5H)-one CAS 102854-63-7
| CAS No. | 102854-63-7 |
| Molecular Formula | C5H3F3O2 |
| Molecular Weight | 152.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Trifluoromethyl)furan-2(5H)-one is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(Trifluoromethyl)furan-2(5H)-one (CAS 102854-63-7) is a high-purity analytical reference standard with the molecular formula C5H3F3O2 and a molecular weight of 152.07 g/mol.
The molecular framework of 4-(Trifluoromethyl)furan-2(5H)-one (C5H3F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3F3O2 |
| Molecular Weight | 152.07 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 2-Methyl-5-(trifluoromethyl)-1,3,4-oxadiazole (CAS 1036648-53-9)
- 3-(Trifluoromethyl)-1H-pyrazol-4-ol (CAS 1394955-16-8)
- 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (CAS 401-73-0)
- 4-(Trifluoromethyl)oxazol-2-amine (CAS 35629-71-1)
- 5-(Trifluoromethyl)-1,3-oxazol-2-amine 5-(trifluoromethyl)oxazol-2-amine 714972-00-6 A9363 (CAS 714972-00-6)
- 1-Methyl-5-(trifluoromethyl)tetrazole (CAS 697-94-9)
- 3-(Trifluoromethyl)cyclopentan-1-one (CAS 1391205-62-1)
- 2-(1-(Trifluoromethyl)cyclopropyl)acetaldehyde (CAS 1934804-69-9)
Recommended Standards
- EGDN (CAS 628-96-6)
- Tetrafluoropyridazine (CAS 7627-80-7)
- 5-Amino-3-(trifluoromethyl)isoxazole (CAS 108655-63-6)
- 2,4,5,6-Tetrafluoropyrimidine (CAS 767-79-3)
- 4-(Aminomethyl)-5-(difluoromethyl)-3-(trifluoromethoxy)picolinaldehyde (CAS 1806169-73-2)
- 5-Bromo-2-(dimethylamino)nicotinonitrile (CAS 1346537-10-7)
- 5α-tetrahydrocortisol d5 (CAS 252976-07-1)
- (2S,3R)-3-(4-Cyanophenyl)-5-oxo-4-(propan-2-yl)thiomorpholine-2-carboxylic acid (CAS 2198400-00-7)
- Plerixafor Impurity 8 4HCl (CAS 176252-20-3(free base))
- Ethyl 5-oxo-1-phenylpyrrolidine-3-carboxylate (CAS 91957-98-1)
- (benzyloxymethyl)piperidine (CAS 37088-21-4)
- 2-Propyl-2,3-dihydrophthalazine-1,4-dione (CAS 103724-41-0)
- 5-Bromo-n-methylthiophene-2-sulfonamide (CAS 81597-52-6)
- Tetrapeptide-3 (CAS 827306-97-8)
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