5-Amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carbonitrile CAS 102996-25-8
| CAS No. | 102996-25-8 |
| Molecular Formula | C10H6F2N4 |
| Molecular Weight | 220.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 5-Amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carbonitrile (CAS 102996-25-8), a certified reference material (molecular formula C10H6F2N4, MW 220.18 g/mol) for analytical method development and quality control.
The molecular framework of 5-Amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carbonitrile (C10H6F2N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H6F2N4 |
| Molecular Weight | 220.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 2-(5-Amino-1,3-dioxoisoindolin-2-yl)acetic acid (CAS 10133-85-4)
- 2-(4-Amino-1,3-dioxoisoindolin-2-yl)acetic acid (CAS 10133-86-5)
- 5-Amino-1-(3,5-difluorophenyl)-1h-pyrazole-4-carbonitrile (CAS 1232780-81-2)
- 5-Amino-1-(3,4-difluorophenyl)-1h-pyrazole-4-carbonitrile (CAS 1416344-53-0)
- 3-Amino-1-propyl-6-(trifluoromethyl)-1,2-dihydropyridin-2-one (CAS 1087800-64-3)
- 2-((4-Amino-2-(trifluoromethyl)phenyl)amino)ethanol (CAS 122862-99-1)
- (S)-2-Amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol (CAS 1427514-98-4)
- 5-Amino-4-methyl-1-(3,3,3-trifluoropropyl)pyridin-2(1h)-one (CAS 1515475-00-9)
Recommended Standards
- Ethyl 4-oxo-4H-pyrido[3,4-d][1,3]oxazine-2-carboxylate (CAS 1029419-85-9)
- 1031577-56-6 Ethyl 3-pyrimidin-2-yl-1,2,4-oxadiazole-5-carboxylate MFCD15732346 (CAS 1031577-56-6)
- Methyl 7-Nitroindole-3-carboxylate (CAS 1027081-37-3)
- 1-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid (CAS 1038385-70-4)
- N-Methylpiperazine-3,3,5,5-d4 (CAS 343864-02-8)
- (S)-2-Amino-4-(ethylamino)-4-oxobutanoic acid (CAS 7195-20-2)
- 2,6-Dichloro-4-pyrimidinepropanoic Acid (CAS 212650-39-0)
- 35675-80-0 I5T6470120 Methyltricaprylylammonium bromide UNII-I5T6470120 1-Octanaminium, N-methyl-N,N-dioctyl-, bromide (1:1) 1-Octanaminium, N-methyl-N,N-dioctyl-, bromide Aliquat 138 Methyltrioctylammonium bromide Trioctylmethylammonium bromide (CAS 35675-80-0)
- 145903-31-7 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 7215AA C10H13NOS (CAS 145903-31-7)
- 1,1,1-Trifluoro-3-[(2-hydroxy-1-phenylethyl)amino]propan-2-ol (CAS 477889-78-4)
- N-(5-Methoxypyrimidin-2-yl)heptanamide (CAS 1057667-16-9)
- 2-Keto-d-gluconic Acid Sodium (CAS CATO-CCFD202183)
- (6E,10E,12E,14E,16E,18E,22E,26E)-2,6,10,14,19,23,27,31-Octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaene (CAS 540-05-6)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com