Decitabine Impurity 31 CAS 1034301-08-0
| CAS No. | 1034301-08-0 |
| Molecular Formula | C22H18Cl2N4O6 |
| Molecular Weight | 505.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Decitabine Impurity 31 (CAS 1034301-08-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H18Cl2N4O6 and a molecular weight of 505.31 g/mol.
Based on its molecular formula C22H18Cl2N4O6, Decitabine Impurity 31 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 505.31 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18Cl2N4O6 |
| Molecular Weight | 505.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Decitabine Standards
- Decitabine Impurity 26 (CAS 1140891-02-6)
- Decitabine Di-Toluoyl Impurity (CAS 10302-79-1)
- Decitabine Impurity 24 (CAS 1207459-15-1)
- Decitabine Impurity 35 (CAS 896451-03-9)
- Decitabine Impurity 36 (CAS 896451-02-8)
- Decitabine impurity 30 (CAS CATO-C4X-113730)
- Decitabine Impurity 48 (CAS CATO-C4X-113748)
- Decitabine Impurity N42 (CAS 58109-18-5)
Recommended Standards
- 2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-N'-[(1Z)-{[(4-chlorophenyl)methoxy]imino}methyl]acetohydrazide (CAS 338979-31-0)
- 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one (CAS 1193165-26-2)
- Tris(di-tert-butylphosphino)gallium (CAS 140194-63-4)
- 2,5-Bis(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)benzoyl)oxy)benzamide (CAS 320418-87-9)
- Axitinib Impurity N7 (CAS 2242852-05-5)
- Dapagliflozin Impurity 68 (CAS 1103738-29-9)
- Lasmiditan Impurity 3 (CAS 613678-08-3)
- Axitinib Impurity 34 (CAS CATO-C4X-107134)
- 4-Aminophenyl dihydrogen phosphate (CAS 52331-30-3)
- 2-(Difluoromethyl)-4-methoxy-3-methylpyridine-6-carboxylic acid (CAS 1805605-45-1)
- Rapamycin Impurity 25 (CAS 151945-42-5 (racemic))
- Ethyl 5-bromo-6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate (CAS 91459-21-1)
- 5-Bromo-4-ethylnicotinic acid (CAS 2167106-90-1)
- Peptide Impurity 27 (CAS 1350456-68-6)
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