Bis(trimethylsilyl) 2,2-difluoromalonate CAS 1034564-84-5
| CAS No. | 1034564-84-5 |
| Molecular Formula | C9H18F2O4Si2 |
| Molecular Weight | 284.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Bis(trimethylsilyl) 2,2-difluoromalonate (CAS 1034564-84-5), molecular formula C9H18F2O4Si2 and molecular weight 284.40 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Bis(trimethylsilyl) 2,2-difluoromalonate (C9H18F2O4Si2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H18F2O4Si2 |
| Molecular Weight | 284.40 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related Bis Standards
- Trimethylsilyl 2,2,3,3,4,4,4-heptafluorobutanoate (CAS 24929-99-5)
- 3,4-Bis((trimethylsilyl)oxy)benzaldehyde (CAS 10586-13-7)
- 1-(Trimethylsilyl)-1-propyn-3-yl Tosylate (CAS 71321-16-9)
- (2,4-Bis((trimethylsilyl)oxy)pyrimidin-5-yl)methanol (CAS 111878-20-7)
- 3-Phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline (CAS 440365-51-5)
- 1-(Phenyl(trimethylsilyl)methyl)-1H-benzo[d][1,2,3]triazole (CAS 131164-33-5)
- N-(2-((Trimethylsilyl)oxy)pyrimidin-4-yl)benzamide (CAS 85743-99-3)
- 3-Methyl-5-(trimethylsilyl)isoxazole-4-boronic Acid Pinacol Ester (CAS 1429913-32-5)
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