1-((Difluoromethyl)sulfonyl)piperazine CAS 1038340-35-0
| CAS No. | 1038340-35-0 |
| Molecular Formula | C5H10F2N2O2S |
| Molecular Weight | 200.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-((Difluoromethyl)sulfonyl)piperazine (C5H10F2N2O2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-((Difluoromethyl)sulfonyl)piperazine (CAS 1038340-35-0) is a high-purity analytical reference standard with the molecular formula C5H10F2N2O2S and a molecular weight of 200.21 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H10F2N2O2S |
| Molecular Weight | 200.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Difluoromethyl Standards
- 2-(difluoromethyl)-1,3-benzothiazol-6-amine (CAS 1468986-20-0)
- 1-(Difluoromethyl)-1h-1,3-benzodiazole-2-thiol (CAS 874623-43-5)
- 2-[(difluoromethyl)thio]-1H-benzimidazole (CAS 321578-79-4)
- 6-(Difluoromethyl)-2-mercapto-4-methylnicotinonitrile (CAS 438218-60-1)
- Ethyl 2-(difluoromethyl)benzoate (CAS 1417503-60-6)
- 3-[4-(Difluoromethyl)phenyl]propanoic Acid (CAS 1546905-68-3)
- (S)-2-(4-(Difluoromethyl)phenyl)propanoic acid (CAS 1630535-98-6)
- (R)-2-(4-(Difluoromethyl)phenyl)propanoic acid (CAS 1630543-20-2)
Recommended Standards
- 4,4-Difluoropiperidine-1-sulfonamide (CAS 1015170-98-5)
- 2-(2-methoxy-2-oxoethyl)thiophene-3-carboxylic acid (CAS 105508-53-0)
- Moroxydine Impurity 2 (CAS CATO-C4X-25802)
- 6,8-Difluorothiochroman-4-one (CAS 1097779-72-0)
- 6-(methylcarbamoyl)pyridine-2-carboxylic acid (CAS 288616-99-9)
- 2-((4-Chlorophenyl)thio)-N-phenethylpropanamide (CAS 332039-40-4)
- 1-Iodo-2,3,4,5,6-pentamethylbenzene (CAS 3853-91-6)
- 4-Amino-1-methylpiperidine (CAS 41838-46-4)
- Teriparatide-d10 TFA Salt (CAS CATO-C4X-21854)
- 2-(Difluoromethyl)-3-hydroxy-5-nitro-6-(trifluoromethyl)pyridine (CAS 1804863-94-2)
- 3-Chloro-2,4,6-trifluorobenzaldehyde (CAS 1160573-14-7)
- 1-(4-Methoxybenzyl)-3-phenylurea (CAS 83196-21-8)
- 7-Fluoro-4-(piperazin-1-yl)quinoline (CAS 643039-93-4)
- Semaglutide Impurity 166 (CAS 1395881-03-4)
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