Famciclovir Impurity 1 CAS 104227-86-3
| CAS No. | 104227-86-3 |
| Molecular Formula | C10H15N5O2 |
| Molecular Weight | 237.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Famciclovir Impurity 1 (CAS 104227-86-3, C10H15N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H15N5O2, Famciclovir Impurity 1 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 237.26 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H15N5O2 |
| Molecular Weight | 237.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 5 |
Related Famciclovir Standards
- Famciclovir Impurity 7 (CAS 2815212-98-5)
- Famciclovir Impurity 2 (CAS 23169-37-1)
- Famciclovir USP Related Compound C (CAS 174155-70-5)
- Famciclovir Impurity 12 (CAS CATO-C4X-164212)
- Famciclovir impurity 3 (CAS 97845-65-3)
- Famciclovir Impurity 10 (CAS CATO-C4X-164210)
- Famciclovir Impurity 27 (CAS CATO-C4X-164227)
- Famciclovir impurity 3 (CAS 172529-94-1)
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- 2-(3-Benzyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1036544-42-9)
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