2,3,5,6-Tetrafluoro-4-methoxybenzenesulfonamide CAS 10459-98-0
| CAS No. | 10459-98-0 |
| Molecular Formula | C7H5F4NO3S |
| Molecular Weight | 259.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,3,5,6-Tetrafluoro-4-methoxybenzenesulfonamide (C7H5F4NO3S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2,3,5,6-Tetrafluoro-4-methoxybenzenesulfonamide (CAS 10459-98-0) is a high-purity analytical reference standard with the molecular formula C7H5F4NO3S and a molecular weight of 259.18 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5F4NO3S |
| Molecular Weight | 259.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Tetrafluoro Standards
- 2,3,4,5-Tetrafluoro-6-methoxybenzenesulfonamide (CAS 2775301-25-0)
- 4,5,6,7-Tetrafluoro-1-isopropyl-1H-indole-3-carbaldehyde (CAS 1350760-54-1)
- 2,2',6,6'-Tetrafluoro-[1,1'-biphenyl]-4,4'-diol (CAS 76463-15-5)
- 5-Methyl-2-(2,3,5,6-tetrafluoro-4-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one (CAS 376593-04-3)
- 6,6,7,7-Tetrafluoro-3-oxabicyclo[3.2.0]Heptane-2,4-dicarboxylic acid (CAS 723-64-8)
- 4,5,6,7-Tetrafluoro-3-(trifluoromethyl)-1H-indazole (CAS 945038-89-1)
- Ethyl 2,3,3,3-tetrafluoro-2-(trifluoromethoxy)propionate (CAS 1823272-01-0)
- 4,5,5,5-Tetrafluoro-4-(trifluoromethoxy)pentanoic acid (CAS 243139-58-4)
Recommended Standards
- 3-(3-(Trifluoromethyl)-1H-pyrazolo[4,3-c]pyridin-1-yl)propanoic acid (CAS 1019115-17-3)
- 3-[4-(Trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 109888-65-5)
- Methyl 5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate (CAS 1018125-80-8)
- Ethyl 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate (CAS 1119429-11-6)
- 4-(4-Methyl-1-piperazinyl)-2-(trifluoromethyl)aniline (CAS 863675-89-2)
- 2-Chloro-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide (CAS 116488-93-8)
- N-Isopropyl-1-(pyridin-3-yl)-1H-pyrazol-4-amine (CAS 28466-02-6)
- 1-Isocyanato-4-(methylsulfonyl)-2-(trifluoromethyl)benzene (CAS 1357627-06-5)
- 3-((o-Tolylamino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione (CAS 370848-29-6)
- Benzenesulfonic acid, hydroxy-, polymer with formaldehyde and urea (CAS 9041-04-7)
- n-(5-Methylisoxazol-3-yl)-4-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide (CAS 793677-83-5)
- 1-(4-Methoxybenzoyl)-2-piperidinecarboxylic acid 1103529-63-0 8715AC C14H17NO4 (CAS 1103529-63-0)
- N-(2-methyl-5-sulfamoylphenyl)acetamide (CAS 17485-44-8)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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