2-Chloro-5-(hydroxymethyl)pyrimidine CAS 1046816-75-4
| CAS No. | 1046816-75-4 |
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | 144.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-(hydroxymethyl)pyrimidine (CAS 1046816-75-4) is a high-purity analytical reference standard with the molecular formula C5H5ClN2O and a molecular weight of 144.56 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 2-Chloro-5-(hydroxymethyl)pyrimidine is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 144.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | 144.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-5-methylpyrimidin-2(1H)-one (CAS 101080-24-4)
- 4-Chloro-2-methylpyrimidin-5-ol (CAS 103660-23-7)
- 5-Chloro-4-methyl-2,3-dihydropyridazin-3-one (CAS 104566-45-2)
- 4-Chloro-5-methyl-1H-pyrazole-3-carbaldehyde (CAS 1050642-24-4)
- 5-Chloro-3-methylpyrazin-2(1H)-one (CAS 105985-18-0)
- 5-Chloro-4-methylpyrimidine 1-oxide (CAS 114969-55-0)
- 5-Chloro-4-methoxypyrimidine (CAS 114969-94-7)
- 4-Chloro-2-hydrazinylpyrimidine (CAS 1158984-54-3)
Recommended Standards
- (4-Chloropyrimidin-2-yl)methanol (CAS 1093880-89-7)
- 2-Amino-4-chloro-3-hydroxypyridine (CAS 1003710-73-3)
- 2-amino-5-chloropyridin-4-ol (CAS 1121585-12-3)
- 5-Chloro-1,1-difluoro-3-oxapentane (CAS 1309602-55-8)
- 2-((4-Methoxybenzyl)thio)-5-((4-nitrobenzyl)thio)-1,3,4-thiadiazole (CAS 618432-18-1)
- Methyl (S,Z)-3-(3-Boc-2,2-dimethyloxazolidin-4-yl)acrylate (CAS 126587-36-8)
- 3-(3,4,5-Trifluorophenyl)-1-propene (CAS 213327-80-1)
- 5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-2-carboxylic acid (CAS 1251000-11-9)
- (2,5-Dichlorophenyl)(phenyl)methanol (CAS 1094791-41-9)
- 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene (CAS 68322-84-9)
- 1-[(Tert-butoxy)carbonyl]-5-methylpiperidine-3-carboxylic acid (CAS 1365887-45-1)
- N2-cyclopentyl-1,3,5-triazine-2,4-diamine (CAS 98427-85-1)
- 1-(Benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxy-3,4-dihydroisoquinoline (CAS 18780-57-9)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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