spiro[indoline-2,4'-piperidine]-3-one CAS 1050596-44-5
| CAS No. | 1050596-44-5 |
| Molecular Formula | C12H20N2O |
| Molecular Weight | 208.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including spiro[indoline-2,4'-piperidine]-3-one.
CATO supplies spiro[indoline-2,4'-piperidine]-3-one (CAS 1050596-44-5), a certified reference material (molecular formula C12H20N2O, MW 208.30 g/mol) for analytical method development and quality control.
The molecular framework of spiro[indoline-2,4'-piperidine]-3-one (C12H20N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20N2O |
| Molecular Weight | 208.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related spiro Standards
- spiro[1,3-dihydroquinazoline-2,1'-cyclopentane]-4-one (CAS 1135-80-4)
- spiro[cyclopropane-2,1-tetralin]-1-carboxylic acid (CAS 1248314-77-3)
- 2H-spiro[1-benzofuran-3,1'-cyclohexan]-4'-one (CAS 179064-52-9)
- 3H-spiro[2-benzofuran-1,1'-cyclohexan]-4'-one (CAS 204192-41-6)
- spiro[isoindoline-3,4'-piperidine]-1-one (CAS 788812-21-5)
- spiro[3,4-dihydro-2H-isoquinoline-1,4'-piperidine] (CAS 173944-07-5)
- spiro[2,3-dihydro-1H-quinoline-4,4'-piperidine] (CAS 873056-19-0)
- spiro[indane-2,3'-tetrahydrofuran]-2',5'-dione (CAS 82054-53-3)
Recommended Standards
- 1-(4-Isobutoxy-3-methylphenyl)ethanol (CAS 1048918-23-5)
- 1-(1-Isopropylpiperidin-4-yl)-1h-pyrazol-5-amine (CAS 1052555-88-0)
- N-(furan-2-ylmethyl)-3-(pyrrolidin-1-yl)propan-1-amine (CAS 1042589-83-2)
- 2-(4-(Isopentyloxy)phenyl)ethan-1-ol (CAS 106379-94-6)
- 1-(dimethylamino)-3-(4-(3-methoxyphenethyl)phenoxy)propan-2-o (CAS CATO-C4X-291335)
- 7,8-Difluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS 1394662-70-4)
- Ethyl 2-(3-chloro-5-methyl-1H-pyrazol-1-yl)acetate (CAS 1015779-06-2)
- 5-Bromo-1,2,4-triazole-3-carbonitrile (CAS 1427475-12-4)
- Methyl 5-(4-fluorobenzoyl)furan-2-carboxylate (CAS 170632-16-3)
- 5-(Trifluoromethyl)pyridine-3-boronic Acid (CAS 947533-51-9)
- 2-(4-(Tert-butyl)phenoxy)acetonitrile (CAS 50635-24-0)
- (11bR)-4-Hydroxy-2,6-bis[4-(2-naphthalenyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin (CAS 699006-55-8)
- 4-(Difluoromethyl)-2-fluoro-3-iodo-6-methoxypyridine (CAS 1806976-26-0)
- Neuropeptide Y (13-36) (human, rat) (CAS 122341-40-6)
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