Ciprofloxacin impurity 43 CAS 105093-21-8
| CAS No. | 105093-21-8 |
| Molecular Formula | C17H18FN3O6S |
| Molecular Weight | 411.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ciprofloxacin impurity 43.
Ciprofloxacin impurity 43 (CAS 105093-21-8) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18FN3O6S and a molecular weight of 411.40 g/mol.
Ciprofloxacin impurity 43 (C17H18FN3O6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18FN3O6S |
| Molecular Weight | 411.40 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ciprofloxacin Standards
- Ciprofloxacin Impurity 15 (CAS 105589-00-2)
- Ciprofloxacin Impurity 17 (CAS 93594-29-7)
- Ciprofloxacin Impurity 34 (CAS CATO-C4X-136234)
- Ciprofloxacin Impurity 13 (CAS CATO-C4X-136213)
- Ciprofloxacin Ethyl Ester (CAS 105404-65-7)
- Ciprofloxacin Impurity 21 (CAS 93594-39-9)
- Ciprofloxacin EP Impurity D (CAS 133210-96-5)
- Ciprofloxacin impurity 45 (CAS 93106-58-2)
Recommended Standards
- tert-Butyl 2'-(((trifluoromethyl)sulfonyl)oxy)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate (CAS 2640496-81-5)
- N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide (CAS 1100353-03-4)
- Methyl 4,6-O-Benzylidene-2-deoxy-2-N-phthalimido-β- D-glucopyranoside (CAS 97276-95-4)
- (3-Bromophenoxy)(tert-butyl)diphenylsilane (CAS 133772-45-9)
- Bisoprolol Impurity 75 (CAS CATO-C4X-124775)
- Cefathiamidine Impurity 14 (CAS CATO-C4X-133714)
- Tadalafil Impurity 75 (CAS 1093940-68-1)
- 3-(3,3-Difluoroazetidin-1-yl)pyrrolidine hydrochloride (CAS 1784688-01-2)
- Benzyl 4-(N'-hydroxycarbamimidoyl)benzoate (CAS 1374664-22-8)
- 4-(Bis(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)methyl)benzoic acid (CAS 905776-24-1)
- Benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4(1H)-one (CAS 257955-44-5)
- 1-Amino-3-(4-methoxyphenoxy)propan-2-ol (CAS 5002-93-7)
- 1-(1-Methylpyrrolidin-3-yl)-1H-pyrazol-4-amine (CAS 1356953-69-9)
- C-telopeptide (CAS 162929-64-8)
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