Cholic Acid Impurity 58 CAS 105227-28-9
| CAS No. | 105227-28-9 |
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cholic Acid Impurity 58 (CAS 105227-28-9, C24H40O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cholic Acid Impurity 58 (C24H40O4) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Cholic Standards
- Cholic acid Impurity 10 (CAS 570-62-7)
- Cholic acid Impurity 11 (CAS 84848-09-9)
- Cholic Acid Impurity 12 (CAS 570-63-8)
- Cholic Acid Impurity 29 (CAS 2024612-46-0)
- Nor Cholic Acid (CAS 60696-62-0)
- Cholic Acid Impurity 14 (CAS CATO-C4X-116014)
- Cholic Acid Impurity 20 (CAS 24637-46-5)
- Cholic Acid Impurity 36 (CAS 24637-45-4)
Recommended Standards
- Allochenodeoxycholic acid (CAS 15357-34-3)
- Ursodeoxycholic Acid EP Impurity E (CAS 83-44-3)
- Ursodeoxycholic acid impurity 31 (CAS 566-17-6)
- Ursodeoxycholic Acid EP Impurity H (CAS 78919-26-3)
- Bimatoprost Impurity 5 (CAS 155206-01-2)
- Crotamiton Impurity 4 (CAS CATO-C4X-19564)
- Vitamin K1 Impurity 77 (CAS CATO-C4X-220777)
- 4-Methyl-1H-pyrazole-3-carbaldehyde (CAS 1284220-50-3)
- 4,4,5,5-Tetramethyl-2-(2-methyl-4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,3,2-dioxaborolane (CAS 2223039-63-0)
- 1-(3-fluoro-4-nitrophenyl)pyridin-2(1H)-one (CAS 896123-18-5)
- SGC0946 (CAS 1561178-17-3)
- 2-Chloro-N-(7-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl)acetamide (CAS 866152-47-8)
- n-(4-Acetylphenyl)cyclopentanecarboxamide (CAS 544679-84-7)
- Neuropeptide W-23 (human) (CAS 383415-79-0)
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