1-[2-(Trifluoromethyl)phenyl]piperidine-4-carboxylic acid CAS 1059536-47-8
| CAS No. | 1059536-47-8 |
| Molecular Formula | C13H14F3NO2 |
| Molecular Weight | 273.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[2-(Trifluoromethyl)phenyl]piperidine-4-carboxylic acid.
1-[2-(Trifluoromethyl)phenyl]piperidine-4-carboxylic acid (CAS 1059536-47-8), molecular formula C13H14F3NO2 and molecular weight 273.25 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[2-(Trifluoromethyl)phenyl]piperidine-4-carboxylic acid (C13H14F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 1-[2-(Trifluoromethyl)phenyl]piperidine-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H14F3NO2 |
| Molecular Weight | 273.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- Methyl 4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylate (CAS 1022224-85-6)
- 1-[3-(Trifluoromethyl)benzyl]pyrrolidine-3-carboxylic acid (CAS 1086375-40-7)
- 1-(4-(Trifluoromethyl)benzyl)pyrrolidine-3-carboxylic acid (CAS 1086380-64-4)
- 1-Methyl-4-[6-(trifluoromethyl)pyridine-3-carbonyl]piperazine (CAS 1092346-41-2)
- 1-Benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid (CAS 1210383-94-0)
- N-[3-(Trifluoromethyl)phenyl]piperazine-1-carboxamide (CAS 1225578-90-4)
- 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid (CAS 186203-08-7)
- (R)-3-(Trifluoromethyl)-7,7a,8,9,10,11-hexahydro-6H-pyrazino[1,2-d]pyrido[3,2-b][1,4]oxazepine (CAS 2830559-80-1)
Recommended Standards
- (2S,4R)-4-(4-(Trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid (CAS 1049981-68-1)
- 3-(3,4-Dimethoxyphenyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol (CAS 1082436-93-8)
- (2S,4R)-4-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid (CAS 1049981-63-6)
- (2S,4R)-4-(2-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid (CAS 1049981-50-1)
- 3-(Thiophen-2-yl)-5-(trifluoromethyl)isoxazole (CAS 175203-89-1)
- 5-Chloro-N1-isobutyl-4-methylbenzene-1,2-diamine (CAS 649763-40-6)
- 6-Bromo-4-fluoropyridazin-3-amine (CAS 2386479-09-8)
- 2-Cyclopropyl-4-fluorophenol (CAS 1232774-27-4)
- 6-(Difluoromethoxy)-1H-indole (CAS 200207-21-2)
- (2S,3S)-2-Amino-3-methylpentanedioic acid hydrochloride (CAS 910548-22-0)
- Fluphenazine Dihydrochloride EP Impurity C (CAS 2518011-27-1)
- Propan-2-one O-mesitylsulfonyl oxime (CAS 81549-07-7)
- 3-(2,3,5-Trimethylphenoxy)piperidine (CAS 946725-76-4)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
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