3-Chloropyridine-2,5-dicarboxylic acid CAS 106014-20-4
| CAS No. | 106014-20-4 |
| Molecular Formula | C7H4ClNO4 |
| Molecular Weight | 201.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Chloropyridine-2,5-dicarboxylic acid (CAS 106014-20-4), molecular formula C7H4ClNO4 and molecular weight 201.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloropyridine-2,5-dicarboxylic acid (C7H4ClNO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4ClNO4 |
| Molecular Weight | 201.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloropyridine Standards
- 5-Chloropyridine-3,4-dicarboxylic acid (CAS 101420-62-6)
- 4-Chloropyridine-2,5-dicarboxylic acid (CAS 1227945-07-4)
- 6-Chloropyridine-2,5-dicarboxylic acid (CAS 1251953-02-2)
- 6-Chloropyridine-2,3-dicarboxylic acid (CAS 127437-44-9)
- 2-Chloropyridine-3,4-dicarboxylic acid (CAS 215306-02-8)
- 4-Chloropyridine-2,3-dicarboxylic acid (CAS 605661-85-6)
- 6-Chloropyridine-3,4-dicarboxylic acid (CAS 243835-70-3)
- Ethyl 6-Chloropyridine-3-acetate (CAS 197376-47-9)
Recommended Standards
- 4-bromo-2-chloro-thiophene (CAS 32431-93-9)
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- 5-Hydroxy-2-nitrobenzoyl chloride (CAS 1261617-16-6)
- 2,5-dichloro-3-(chloromethyl)thiophene (CAS 10095-91-7)
- 2-(1-(Phenylthio)cyclopropyl)but-3-en-2-ol (CAS 41596-96-7)
- 3-Methyl-1,2,4-triazin-6-amine (CAS 1384878-44-7)
- N-(6-acetylbenzo[d][1,3]dioxol-5-yl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide (CAS 1023518-48-0)
- 3-Chloro-4-fluoro-N-(3-fluorobenzyl)aniline (CAS 1040309-97-4)
- 6-Methoxy-4-((trimethylsilyl)ethynyl)pyridin-3-amine (CAS 227180-22-5)
- tert-Butyl (2-(4-formyl-6-methoxypyridin-2-yl)ethyl)carbamate (CAS 1393543-19-5)
- 2-Amino-N-(2-(furan-2-yl)-2-oxoethyl)-N-isopropylacetamide (CAS 1353963-18-4)
- 1-[(2H-1,3-Benzodioxol-5-yl)methyl]-5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-dihydropyrimidin-4-one (CAS 477888-17-8)
- 4-Ethoxy-4-oxo-3-phenylbutanoic acid (CAS 32971-21-4)
- Insulin Lispro (CAS 133107-64-9)
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