tert-Butyl 2-hydroxy-2-(6-methylpyridin-2-yl)acetate CAS 1060803-75-9
| CAS No. | 1060803-75-9 |
| Molecular Formula | C12H17NO3 |
| Molecular Weight | 223.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 2-hydroxy-2-(6-methylpyridin-2-yl)acetate (CAS 1060803-75-9) is a high-purity analytical reference standard with the molecular formula C12H17NO3 and a molecular weight of 223.27 g/mol.
The molecular framework of tert-Butyl 2-hydroxy-2-(6-methylpyridin-2-yl)acetate (C12H17NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), tert-Butyl 2-hydroxy-2-(6-methylpyridin-2-yl)acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H17NO3 |
| Molecular Weight | 223.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 1 |
Recommended Standards
- tert-Butyl (2-(aminomethyl)pyridin-3-yl)carbamate (CAS 1060803-71-5)
- Tert-butyl (5-amino-4-methylpyridin-2-yl)carbamate (CAS 1062134-50-2)
- (6-Aminomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (CAS 1060801-10-6)
- 1-(6-Ethoxypyrimidin-4-yl)piperidin-4-ol (CAS 1065484-28-7)
- [1-(2,2,2-trifluoroethyl)-1h-imidazol-2-yl]methanol (CAS 135206-92-7)
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- 4-Acetylphenyl chloroformate (CAS 54888-20-9)
- D-[Val]10-Semaglutide (CAS CATO-CPTD788630)
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