4-chloro-5-hydroxy-pyridine-2-carboxylic acid CAS 1060804-56-9
| CAS No. | 1060804-56-9 |
| Molecular Formula | C6H10ClNO3 |
| Molecular Weight | 179.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-chloro-5-hydroxy-pyridine-2-carboxylic acid (CAS 1060804-56-9), molecular formula C6H10ClNO3 and molecular weight 179.60 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-chloro-5-hydroxy-pyridine-2-carboxylic acid (C6H10ClNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10ClNO3 |
| Molecular Weight | 179.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 3-Chloroquinolin-8-ol (CAS 102878-83-1)
- 5-Chloroquinolin-4(1H)-one (CAS 101774-49-6)
- Ethyl (1R,2R)-2-Aminocyclopentanecarboxylate (CAS 1609100-30-2)
- ethyl 5-amino-1,3-thiazole-2-carboxylate hydrochloride (CAS 1803583-69-8)
- 4-Imino-1-oxa-3-azaspiro[4.5]decan-2-one (CAS 1698043-89-8)
- LY 353433 (CAS 176390-32-2)
- 4-Chloro-5-(difluoromethyl)-2-fluoronicotinic acid (CAS 1806935-55-6)
- Phenol, 2-(1,1-dimethylethyl)-, polymer with 2-(chloromethyl)oxirane and 4,4'-(1-methylethylidene)bis[phenol] (CAS 70715-08-1)
- 3-(Pyrrolidin-1-yl)furan-2,5-dione (CAS 180903-37-1)
- 2-(3-Chloro-4-fluorophenyl)pyridin-4-ol (CAS 1262011-49-3)
- 5-Chloro-2-methylsulfanyl-1,3-benzothiazole (CAS 3507-41-3)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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