8-Bromo-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylic acid CAS 1065093-77-7
| CAS No. | 1065093-77-7 |
| Molecular Formula | C11H5BrF3NO3 |
| Molecular Weight | 336.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Bromo-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Bromo-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 1065093-77-7), molecular formula C11H5BrF3NO3 and molecular weight 336.06 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 8-Bromo-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylic acid (C11H5BrF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H5BrF3NO3 |
| Molecular Weight | 336.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 5-Bromo-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 1065093-66-4)
- 8-Bromo-4-hydroxy-5-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 1065093-69-7)
- 6-Bromo-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 1065093-84-6)
- 6-Bromo-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 1065093-93-7)
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