Ethyl 5-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate CAS 1065102-41-1
| CAS No. | 1065102-41-1 |
| Molecular Formula | C13H9F4NO3 |
| Molecular Weight | 303.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 5-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ethyl 5-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-41-1), a certified reference material (molecular formula C13H9F4NO3, MW 303.21 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 5-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (C13H9F4NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 5-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9F4NO3 |
| Molecular Weight | 303.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 8-fluoro-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065094-19-0)
- Ethyl 6-fluoro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-32-0)
- Ethyl 8-fluoro-4-hydroxy-5-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-39-7)
- Ethyl 6-fluoro-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate (CAS 26893-01-6)
- 4-Fluoro-2-methyl-5-nitrophenyl trifluoromethanesulfonate (CAS 1820734-74-4)
- 2-Fluoro-4-methyl-5-nitrophenyl trifluoromethanesulfonate (CAS 1980076-30-9)
- 3-(2-Fluoro-4-nitrophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1823188-35-7)
- (3-Fluoro-benzyl)-(2-pentafluoroethylsulfanylethyl)-amine (CAS 1208079-61-1)
Recommended Standards
- N-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 1073354-35-4)
- 1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)piperazine (CAS 1171892-37-7)
- 4-Bromo-2-fluoro-1-(octyloxy)benzene (CAS 119259-26-6)
- 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)azepane (CAS 1015242-05-3)
- 1-Oxo-2,3,4,9-tetrahydro-1H-b-carboline-6-carboxylic acid (CAS 1751-78-6)
- tert-Butyl ((R)-1-((S)-2-aminopropanoyl)pyrrolidin-3-yl)(isopropyl)carbamate (CAS 1401669-03-1)
- Methyl 3,3-dimethyl-4-oxopentanoate (CAS 40484-80-8)
- Elacestrant impurity 10 (CAS CATO-C4X-32330)
- 6-Phenyl-5-hexenoic Acid (CAS 16424-56-9)
- 1-Amino-3-methyl-2-(1-pyrrolidinyl)butane (CAS 929343-27-1)
- 8-Bromo-5-chloro-[1,2,4]triazolo[1,5-c]pyrimidine (CAS 1367774-82-0)
- 1-Amino-4-benzylpiperazine (CAS 39139-52-1)
- 6-Amino-1-(3-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde (CAS 910443-02-6)
- Glucagon receptor antagonist I (CAS 438618-32-7)
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