5-Chlorothiophen-2-amine hydrochloride CAS 1070886-43-9
| CAS No. | 1070886-43-9 |
| Molecular Formula | C4H4ClNS |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chlorothiophen-2-amine hydrochloride is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-Chlorothiophen-2-amine hydrochloride (CAS 1070886-43-9), a certified reference material (molecular formula C4H4ClNSHCl, MW 170.05 g/mol) for analytical method development and quality control.
The molecular framework of 5-Chlorothiophen-2-amine hydrochloride (C4H4ClNSHCl) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H4ClNS HCl |
| Molecular Weight | 170.05 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorothiophen Standards
- 3-(5-Chlorothiophen-2-yl)propan-1-ol (CAS 1000542-40-4)
- 3-(5-Chlorothiophen-2-yl)propan-1-amine (CAS 1000564-79-3)
- 3-(4-Chlorothiophen-2-yl)propan-1-ol (CAS 1000573-55-6)
- 2'-[4-(3-Chlorothiophen-2-yl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-5,5'-dimethyl-2H,2'H-[3,4'-bipyrazole]-3'-ol (CAS 1007030-99-0)
- 1-(1-(4-(3-chlorothiophen-2-yl)thiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)butane-1,3-dione (CAS 1007033-71-7)
- 2'-[4-(3-Chlorothiophen-2-yl)-1,3-thiazol-2-yl]-2-(2,4-dichlorophenyl)-5,5'-dimethyl-2H,2'H-[3,4'-bipyrazole]-3'-ol (CAS 1007073-49-5)
- 1-[(5-chlorothiophen-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid (CAS 1007999-30-5)
- N-(4-(5-Chlorothiophen-2-yl)thiazol-2-yl)-2-(2-oxobenzo[d]oxazol-3(2H)-yl)acetamide (CAS 1012480-95-3)
Recommended Standards
- 3,6,9,12,15-Pentaoxaheptadecan-1-ol (CAS 4353-29-1)
- 2-(5-Chloro-1H-pyrrolo[2,3-c]pyridin-3-yl)acetic acid hydrochloride (CAS 2138155-01-6)
- BDTT26F-2Sn (CAS 2304446-45-3)
- Pregabalin Impurity PD 0224377 (CAS CATO-C4X-13128)
- 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1151564-17-8)
- 3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine (CAS 1306606-75-6)
- 6-Fluoro-6'-methoxy-2,2'-bipyridine (CAS 1245646-08-5)
- N-(4-chlorophenyl)aminosulfonamide (CAS 98198-68-6)
- N,N-BIs-boc-2-bromo-3-methoxy-phenylamine (CAS 1935989-83-5)
- Liraglutide Impurity 26 (CAS CATO-C4X-199226)
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