(8β)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]ergoline CAS 1075250-74-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (8β)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]ergoline.

(8β)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]ergoline (CAS 1075250-74-6), molecular formula C21H32N2OSi and molecular weight 356.58 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (8β)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]ergoline (C21H32N2OSi) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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