Cilastatin Impurity 21 CAS 107872-23-1
| CAS No. | 107872-23-1 |
| Molecular Formula | C16H26N2O5S |
| Molecular Weight | 358.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Cilastatin Impurity 21 (CAS 107872-23-1, C16H26N2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cilastatin Impurity 21 (C16H26N2O5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 358.45 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H26N2O5S |
| Molecular Weight | 358.45 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Cilastatin Standards
- Cilastatin Sodium - Impurity G (CAS 1174657-12-5)
- Cilastatin (CAS 82009-34-5)
- Cilastatin Impurity 14 (CAS 78852-98-9)
- Cilastatin EP Impurity G (CAS CATO-C4X-196016)
- Cilastatin E-isomer Impurity 18 (CAS CATO-C4X-196018)
- Cilastatin EP Impurity F (CAS CATO-C4X-19604)
- Cilastatin EP Impurity G (CAS CATO-C4X-196040)
- Cilastatin Impurity 45 (CAS CATO-C4X-196045)
Recommended Standards
- (S,S)-Cilastatin (CAS 107873-05-2)
- Imipenem Impurity 131 (CAS CATO-C4X-1662131)
- Cilastatin enantiomer (CAS 107872-24-2)
- Pioglitazone impurity 58 (CAS CATO-C4X-138358)
- Vericiguat Impurity 61 (CAS CATO-C4X-289661)
- Benserazide EP Impurity B Ethanol (CAS 2472968-83-3（free base）)
- Posaconazole Impurity 87 (CAS 1230634-17-9)
- 4-[(4-Nitrophenoxy)acetyl]morpholine (CAS 50508-33-3)
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