Formoterol Impurity 72 CAS 108971-53-5
| CAS No. | 108971-53-5 |
| Molecular Formula | C17H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Formoterol Impurity 72 (C17H21NOHCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Formoterol Impurity 72 (CAS 108971-53-5, C17H21NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO HCl |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Formoterol Standards
- Formoterol Impurity 69 (CAS 100865-09-6)
- Formoterol-d6(Mixture of Diastereomers) (CAS 1020719-45-2)
- Formoterol Impurity 22 HCl (CAS 1049695-95-5)
- Formoterol EP Impurity B (CAS 1224588-66-2)
- Formoterol Impurity 19 (CAS 126002-14-0)
- Formoterol Impurity 28 (CAS 126587-86-8)
- Formoterol (Mixture of Diastereomers) (CAS 128954-45-0)
- Formoterol impurity 103 (CAS 1346746-81-3)
Recommended Standards
- Carbetocin Impurity 20 (CAS CATO-C4X-191120)
- Aciclovir EP Impurity I (CAS 1797832-75-7)
- Epinastine Impurity 39 (CAS CATO-C4X-184039)
- 7-Amino-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 420788-05-2)
- trans-1,3-Dimethyl-piperidin-4-ylamine dihydrochloride (CAS 2089381-13-3)
- Pterolactam (CAS 38072-88-7)
- Piperazine-2,6-dione (CAS 4774-22-5)
- 3-Methyl-1-phenyl-4-(propan-2-ylidene)-1H-pyrazol-5(4H)-one (CAS 22123-17-7)
- N,N-Dimethyl-3-phenyl-1H-indene-2-ethanamine-d5 Hydrobromide (CAS 1346597-99-6)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
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