N2,N6-Bis(4-chlorophenyl)-4-(trifluoromethyl)pyridine-2,6-dicarboxamide CAS 1092344-82-5
| CAS No. | 1092344-82-5 |
| Molecular Formula | C20H12Cl2F3N3O2 |
| Molecular Weight | 454.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N2,N6-Bis(4-chlorophenyl)-4-(trifluoromethyl)pyridine-2,6-dicarboxamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N2,N6-Bis(4-chlorophenyl)-4-(trifluoromethyl)pyridine-2,6-dicarboxamide (CAS 1092344-82-5), molecular formula C20H12Cl2F3N3O2 and molecular weight 454.23 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N2,N6-Bis(4-chlorophenyl)-4-(trifluoromethyl)pyridine-2,6-dicarboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 454.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H12Cl2F3N3O2 |
| Molecular Weight | 454.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- Resmetirom impurity 15 (CAS 920509-35-9)
- N2,N6-bis(2-chlorophenyl)-4-(trifluoromethyl)pyridine-2,6-dicarboxamide (CAS 1092344-85-8)
- C-(2,3,4,6-Tetra-O-acetyl-1-bromo-1-deoxy-b-D-galactopyranosyl)formamide (CAS 159895-07-5)
- Prop-2-yn-1-yl 3-ethoxy-4-((2-fluorobenzyl)oxy)-5-iodobenzoate (CAS 1706439-89-5)
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- N1-((1-(Hydroxymethyl)cyclopropyl)methyl)-N2-(thiophen-2-ylmethyl)oxalamide (CAS 1251560-58-3)
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- Methyl 2-((4-chlorophenyl)thio)acetate (CAS 15446-15-8)
- 2-[4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-5,6-dihydro-4H-1,3-oxazine (CAS 2377606-41-0)
- 4-(((4-Chlorophenyl)sulfonamido)methyl)benzoic acid (CAS 138914-23-5)
- (3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol (CAS 1632118-70-7)
- 2-(2-Methoxyphenyl)hydrazine-1-sulfonic acid (CAS 773803-87-5)
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