5-[4-(difluoromethoxy)phenyl]thiophene-2-carboxylic acid CAS 1096977-35-3
| CAS No. | 1096977-35-3 |
| Molecular Formula | C12H8F2O3S |
| Molecular Weight | 270.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 270.25 g/mol gives 5-[4-(difluoromethoxy)phenyl]thiophene-2-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 5-[4-(difluoromethoxy)phenyl]thiophene-2-carboxylic acid (CAS 1096977-35-3), a certified reference material (molecular formula C12H8F2O3S, MW 270.25 g/mol) for analytical method development and quality control.
Structurally, 5-[4-(difluoromethoxy)phenyl]thiophene-2-carboxylic acid (C12H8F2O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 270.25 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-[4-(difluoromethoxy)phenyl]thiophene-2-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8F2O3S |
| Molecular Weight | 270.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
- 9-(2-Nitrobenzyl)-9H-purin-6-amine (CAS 10549-96-9)
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- 2-(Trifluoromethyl)-2’,3’,4’,5’-tetrahydrobiphenyl-4-carboxylic Acid (CAS 1034188-31-2)
- (3,5-Dimethyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)methanol (CAS 1175961-05-3)
- (R)-2-Amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid (CAS 4043-91-8)
- N-(3,4-Dichlorophenyl)-3-(trifluoromethyl)benzamide (CAS 24094-75-5)
- 3-Chloro-4-isothiocyanatobenzonitrile (CAS 402714-30-1)
- Ethyl 6-Fluoroquinoline-3-carboxylate (CAS 71083-14-2)
- VX 745 (CAS 209410-46-8)
- (S)-1,1,1-trifluoro-2-hexylamine (CAS 1344635-30-8)
- (r)-2-Amino-2-(5-fluoro-2-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1213624-27-1)
- 3,4,6-Trichloro-2-iodophenol (CAS 35020-03-2)
- 7-Chloro-4-methyl-2-oxo-1,2-dihydroquinoline-6-sulfonamide (CAS 1222859-24-6)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
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