1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol CAS 1105189-30-7

Purity 97%+In StockPharmaceutical Standards
CAS No.1105189-30-7
Molecular FormulaC16H11F2N3O3S
Molecular Weight363.34 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol CAS 1105189-30-7 chemical structure

Description

The occurrence of 1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol (CAS 1105189-30-7) is a high-purity analytical reference standard with the molecular formula C16H11F2N3O3S and a molecular weight of 363.34 g/mol.

1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol (C16H11F2N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-[4-(Difluoromethoxy)phenyl]-5-(3-nitrophenyl)-1H-imidazole-2-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC16H11F2N3O3S
Molecular Weight363.34 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1989
Halogen ContentF-containing
Nitrogen Atoms3
Sulfur Atoms1

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