5-(4-Bromophenyl)-1-(4-fluorophenyl)-1h-imidazole-2-thiol CAS 1105189-86-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Bromophenyl)-1-(4-fluorophenyl)-1h-imidazole-2-thiol.

5-(4-Bromophenyl)-1-(4-fluorophenyl)-1h-imidazole-2-thiol (CAS 1105189-86-3), molecular formula C15H10BrFN2S and molecular weight 349.22 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/bromine substitution, 5-(4-Bromophenyl)-1-(4-fluorophenyl)-1h-imidazole-2-thiol is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 349.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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