2-(Pyrazine-2-carboxamido)thiazole-4-carboxylic acid CAS 1105192-33-3
| CAS No. | 1105192-33-3 |
| Molecular Formula | C9H6N4O3S |
| Molecular Weight | 250.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Pyrazine-2-carboxamido)thiazole-4-carboxylic acid (CAS 1105192-33-3) is a high-purity analytical reference standard with the molecular formula C9H6N4O3S and a molecular weight of 250.23 g/mol.
The molecular framework of 2-(Pyrazine-2-carboxamido)thiazole-4-carboxylic acid (C9H6N4O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-(Pyrazine-2-carboxamido)thiazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6N4O3S |
| Molecular Weight | 250.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Pyrazine Standards
- 1-(Pyrazine-2-carboxamido)cyclohexanecarboxylic acid (CAS 402959-98-2)
- 4-(Pyrazine-2-carbonyl)-3,4-dihydroquinoxalin-2(1H)-one (CAS 851819-83-5)
- Pyrazine-2,3,5,6-tetracarboxylic acid (CAS 43193-60-8)
- 4-(Pyrazine-2-carboxamido)benzoic acid (CAS 717854-83-6)
- Methyl 2-(pyrazine-2-amido)benzoate (CAS 69873-69-4)
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Recommended Standards
- Ethyl 1-(diethoxyphosphoryl)cyclopropanecarboxylate (CAS 104585-94-6)
- 3-(4-Fluorophenyl)-2-(5-methyl-1h-1,2,3,4-tetrazol-1-yl)propanoic acid (CAS 1118787-16-8)
- Ethyl 1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate (CAS 1034303-23-5)
- 3-(3-Fluorophenyl)-2-(5-methyl-1h-1,2,3,4-tetrazol-1-yl)propanoic acid (CAS 1118787-20-4)
- [3-(Prop-2-yn-1-yloxy)phenyl]amine (CAS 60042-20-8)
- tert-Butyl ((3R,4S)-3-fluoropiperidin-4-yl)carbamate (CAS 1630815-57-4)
- 3-(azetidin-3-yloxy)pyrrolidine dihydrochloride (CAS 2306275-36-3)
- 3-Bromo-4-(trifluoromethoxy)benzoic acid (CAS 85373-96-2)
- Tert-butyl 6-amino-1,1-dimethylisoindoline-2-carboxylate (CAS 2227205-25-4)
- 6-Bromo-2-(pyridin-3-yl)quinoline-4-carbonyl chloride (CAS 1203220-43-2)
- 4-chloro-2-(pyridin-3-yl)phenol (CAS 1214337-83-3)
- 5-Bromo-3-(difluoromethyl)-2-methylpyridin-4-amine (CAS 1805259-70-4)
- Isatoribine (CAS 122970-40-5)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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