Lusutrombopag Impurity 6 CAS 1110767-77-5
| CAS No. | 1110767-77-5 |
| Molecular Formula | C29H32Cl2N2O5S |
| Molecular Weight | 591.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lusutrombopag Impurity 6 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lusutrombopag Impurity 6 (CAS 1110767-77-5, C29H32Cl2N2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lusutrombopag Impurity 6 (C29H32Cl2N2O5S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H32Cl2N2O5S |
| Molecular Weight | 591.55 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lusutrombopag Standards
- Lusutrombopag (CAS 1110766-97-6)
- Lusutrombopag Impurity 13 (CAS CATO-C4X-208413)
- Lusutrombopag Z-isomer (CAS CATO-C4X-208414)
- Lusutrombopag Impurity 41 (CAS CATO-C4X-208441)
- Lusutrombopag Impurity 59 (CAS CATO-C4X-208459)
- Lusutrombopag Impurity 71 (CAS CATO-C4X-208471)
- Lusutrombopag-d13 (CAS CATO-C4X-20841)
- Lusutrombopag Impurity 60 (CAS CATO-C4X-208460)
Recommended Standards
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