5-(3-Chloro-4-fluorophenyl)pyrimidin-2-ol CAS 1111107-97-1
| CAS No. | 1111107-97-1 |
| Molecular Formula | C10H6ClFN2O |
| Molecular Weight | 224.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(3-Chloro-4-fluorophenyl)pyrimidin-2-ol.
5-(3-Chloro-4-fluorophenyl)pyrimidin-2-ol (CAS 1111107-97-1), molecular formula C10H6ClFN2O and molecular weight 224.62 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C10H6ClFN2O, 5-(3-Chloro-4-fluorophenyl)pyrimidin-2-ol contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 224.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(3-Chloro-4-fluorophenyl)pyrimidin-2-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClFN2O |
| Molecular Weight | 224.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-6-(3-fluorophenoxy)pyrimidine (CAS 1017067-02-5)
- 2-chloro-4-(4-fluorophenoxy)pyrimidine (CAS 1090835-72-5)
- 5-(3-chloro-4-fluorophenyl)-1,2,4-triazin-3-amine (CAS 1094231-67-0)
- 5-(3-Chloro-5-fluorophenyl)pyrimidin-2-ol (CAS 1111113-16-6)
- 4-(4-Chloro-1h-pyrazol-1-yl)-3-fluorobenzaldehyde (CAS 1178311-05-1)
- 2-(4-Chloro-1h-pyrazol-1-yl)-5-fluorobenzaldehyde (CAS 1183264-59-6)
- 2-Chloro-4-(3-fluorophenoxy)pyrimidine (CAS 1242240-84-1)
- (3-Chloro-4-fluorophenyl)(furan-2-yl)methanone (CAS 1342788-79-7)
Recommended Standards
- 4-(Chlorosulfonyl)-5-methylfuran-2-carboxylic acid (CAS 1016760-03-4)
- Methyl 2-(chlorosulfonyl)furan-3-carboxylate (CAS 1011241-51-2)
- methyl 5-chlorosulfonylfuran-3-carboxylate (CAS 1306607-16-8)
- 5-Chloro-N,N-dimethyl-6-(trifluoromethyl)pyridin-2-amine (CAS 2813245-29-1)
- 5-Chloro-2-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic acid (CAS 292058-57-2)
- N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methylpyrimidin-4-amine (CAS 748084-03-9)
- 2-((2,4-Dichlorobenzyl)thio)ethanol (CAS 89040-06-2)
- 5-(Piperazin-2-yl)-1,2,4-oxadiazol-3-amine (CAS 129594-95-2)
- N-(4-Methylbenzyl)-2-(2-oxo-5-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyridin-1(2H)-yl)butanamide (CAS 1396633-93-4)
- 2-(Quinolin-6-yl)acetic acid (CAS 5622-34-4)
- 2-(2-Methylpiperazin-1-yl)pyrazine dihydrochloride (CAS 2138093-56-6)
- (S)-1-((tert-butoxycarbonyl)glycyl)-4,4-difluoropyrrolidine-2-carboxylic acid (CAS 2306252-51-5)
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