N-((5-Chloropyrimidin-2-yl)carbamoyl)-2,6-difluorobenzamide CAS 111604-44-5
| CAS No. | 111604-44-5 |
| Molecular Formula | C12H7ClF2N4O2 |
| Molecular Weight | 312.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
N-((5-Chloropyrimidin-2-yl)carbamoyl)-2,6-difluorobenzamide (CAS 111604-44-5), molecular formula C12H7ClF2N4O2 and molecular weight 312.66 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-((5-Chloropyrimidin-2-yl)carbamoyl)-2,6-difluorobenzamide (C12H7ClF2N4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), N-((5-Chloropyrimidin-2-yl)carbamoyl)-2,6-difluorobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF2N4O2 |
| Molecular Weight | 312.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
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- N-(2-Chloropyrimidin-4-yl)-3-(4-methoxyphenyl)isoxazol-5-amine (CAS 2408588-57-6)
- Ethyl 2-(2-chloropyrimidin-4-yl)-1H-indole-5-carboxylate (CAS 916486-04-9)
- 4-(2-Chloropyrimidin-4-yl)-2-morpholinobenzonitrile (CAS 1206970-30-0)
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Recommended Standards
- 32395-58-7 dimethyl(octadecyl)silane dimethyloctadecylsilane (CAS 32395-58-7)
- 1-(4-(Trifluoromethyl)pyrimidin-2-yl)-1H-pyrazole-4-sulfonyl chloride (CAS 1215564-15-0)
- 8-Chloro-1,5-naphthyridin-2-yl trifluoromethanesulfonate (CAS 1092565-20-2)
- N-(4-chlorophenyl)-2,6-difluoro-3-nitrobenzamide (CAS 260442-70-4)
- 2-(3,4-Dimethoxyphenyl)-6-methylquinoline-4-carbohydrazide (CAS 590355-39-8)
- 2-Hydroxybutanoic-d3 Acid Sodium Salt (CAS 1219798-97-6)
- 2-(Difluoromethyl)-4-iodo-3-methylpyridine-6-acetonitrile (CAS 1805265-29-5)
- 6-hydroxyquinoline-2-carboxylic acid (CAS 75434-18-3)
- 2,2,2-trifluoroethyl 4-cyanophenylcarbamate (CAS 1000932-40-0)
- 4,6-Dimethoxy-2,3,5-trimethylbenzofuran (CAS 831171-05-2)
- 1H-Indazole-4-carbaldehyde (CAS 669050-70-8)
- Griseofulvin-13C,d3 (CAS 1329612-29-4)
- 5-(Piperidin-1-ylmethyl)pyridin-3-amine (CAS 1083181-74-1)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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