4-[Bis(4-Fluorophenyl)methylene]-piperidine hydrobromide CAS 111627-29-3
| CAS No. | 111627-29-3 |
| Molecular Formula | C18H17F2N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[Bis(4-Fluorophenyl)methylene]-piperidine hydrobromide.
4-[Bis(4-Fluorophenyl)methylene]-piperidine hydrobromide (CAS 111627-29-3), molecular formula C18H17F2NHBr and molecular weight 366.25 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-[Bis(4-Fluorophenyl)methylene]-piperidine hydrobromide (C18H17F2NHBr) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-[Bis(4-Fluorophenyl)methylene]-piperidine hydrobromide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H17F2N HBr |
| Molecular Weight | 366.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 3-[(3-fluorophenyl)methyl]pyrrolidine (CAS 1000198-80-0)
- 3-(3-Fluorophenyl)-3-oxopropanoic acid (CAS 1000530-96-0)
- Ethyl 1-(4-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000573-68-1)
- 1000574-26-4 2-(4-Fluorophenyl)-6-methylthio-4H-thiopyran-4-one MFCD09877819 (CAS 1000574-26-4)
- Ethyl 1-(2-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000575-18-7)
- 100074-04-2 5-(4-Fluorophenyl)-1-pentene MFCD11553774 (CAS 100074-04-2)
- 3-(2-Fluorophenyl)-4-hydroxyfuran-2(5H)-one (CAS 100074-44-0)
- N-[2-(4-fluorophenyl)ethyl]-1H-imidazole-1-carboxamide (CAS 1000931-75-8)
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- (1S,1'S)-1,1'-(pyridine-2,6-diyl)bis(ethan-1-ol) (CAS 143329-85-5)
- (2-((2-(Dimethylamino)ethyl)amino)pyridin-4-yl)boronic acid (CAS 1704064-35-6)
- Diisopropyl (4-bromobutyl)phosphonate (CAS 147461-17-4)
- 4-((3-Methyl-3H-diazirin-3-yl)methyl)-1,2-diphenylpyrazolidine-3,5-dione (CAS 29301-73-3)
- (2E)-3-(Dimethylamino)-1-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}prop-2-en-1-one (CAS 499796-73-5)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
Why CATO?
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