methyl 2-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate CAS 1118787-91-9
| CAS No. | 1118787-91-9 |
| Molecular Formula | C7H5Cl2NO4S |
| Molecular Weight | 270.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of methyl 2-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies methyl 2-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate (CAS 1118787-91-9), a certified reference material (molecular formula C7H5Cl2NO4S, MW 270.09 g/mol) for analytical method development and quality control.
The molecular framework of methyl 2-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate (C7H5Cl2NO4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), methyl 2-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl2NO4S |
| Molecular Weight | 270.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related methyl Standards
- Methyl 6-chloro-5-(chlorosulfonyl)pyridine-3-carboxylate (CAS 1118787-95-3)
- 2-chloro-3-methyl-5-nitrobenzene-1-sulfonyl chloride (CAS 1156136-99-0)
- (2-Chloro-5-nitrophenyl)methanesulfonyl chloride (CAS 1250693-09-4)
- (2-Chloro-6-nitrophenyl)methanesulfonyl chloride (CAS 1339221-99-6)
- methyl 6-chloro-3-(chlorosulfonyl)pyridine-2-carboxylate (CAS 1384429-79-1)
- Methyl 4-chloro-6-(chlorosulfonyl)picolinate (CAS 1393531-06-0)
- Methyl 2-chloro-6-(chlorosulfonyl)isonicotinate (CAS 1393548-02-1)
- (5-Chloro-2-nitrophenyl)methanesulfonyl chloride (CAS 1540471-57-5)
Recommended Standards
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- N-(4-Bromophenyl)maleamic acid (CAS 59256-47-2)
- 4-fluoro-3-iodo-1H-pyrrolo[3,2-c]pyridine (CAS 1190309-79-5)
- 1-tert-Butyl 3-methyl 4-((2,4-dichloropyrimidin-5-yl)methyl)piperazine-1,3-dicarboxylate (CAS 2700529-05-9)
- (3aR,7aS)-2-[(2-Methylpropan-2-yl)oxycarbonyl]-5-phenylmethoxycarbonyl-1,3,3a,4,6,7-hexahydropyrrolo[3,4-c]pyridine-7a-carboxylic acid (CAS 1217630-99-3)
- N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide (CAS 1191911-26-8)
- (1-(5-Hydroxypentyl)-1H-indol-3-yl)(4-hydroxyphenyl)methanone (CAS 1952336-77-4)
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